|?|| (C;C) (C;G) (G;G) ||28|
( 366C/G / Pro122Pro ) is a SNP within GRIN2B
(Glutamate [NMDA] receptor subunit epsilon-2).
[PMID 19562769] small study (consisting of 404 Parkinson's patients) found association of the CC genotype with increased incidence of impulsive control and related behaviors
no assoc. noted with
[PMID 19605943] lithium response and [PMID 19005876] bipolar disorder with any GRIN2B SNPs tested (366G/C, -200G/T and rs890)
[PMID 15542698] alcoholism
[PMID 12824739] treatment-refractory schizophrenia - 'not a major risk factor', higher mean clozapine dosage noted with the rs1806201(C;C) genotype
[PMID 19911060] Persistence criteria for susceptibility genes for schizophrenia: a discussion from an evolutionary viewpoint.
[PMID 20537720] Positive association between GRIN2B gene and bipolar disorder in the Chinese Han Population.
[PMID 24114429] A study of N-methyl-D-aspartate receptor gene (GRIN2B) variants as predictors of treatment-resistant major depression
[PMID 23408766] Assessment of NMDA receptor genes (GRIN2A, GRIN2B and GRIN2C) as candidate genes in the development of degenerative lumbar scoliosis.