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rs7310409

From SNPedia

Orientationplus
Stabilizedplus
Make rs7310409(A;A)
Make rs7310409(A;G)
Make rs7310409(G;G)
ReferenceGRCh38 38.1/141
Chromosome12
Position120987058
GeneHNF1A
is asnp
is mentioned by
dbSNPrs7310409
ebirs7310409
HLIrs7310409
Exacrs7310409
Varsomers7310409
Maprs7310409
PheGenIrs7310409
hapmaprs7310409
1000 genomesrs7310409
hgdprs7310409
ensemblrs7310409
gopubmedrs7310409
geneviewrs7310409
scholarrs7310409
googlers7310409
pharmgkbrs7310409
gwascentralrs7310409
openSNPrs7310409
23andMers7310409
23andMe allrs7310409
SNP Nexus

SNPshotrs7310409
SNPdbers7310409
MSV3drs7310409
GWAS Ctlgrs7310409
GMAF0.3935
Max Magnitude
A study of 12,854 Japanese subjects replicated the finding of an association between rs7310409 and serum CRP levels.[PMID 21196492]
? (A;A) (A;G) (G;G) 28
GWAS
SNP rs7310409
PubMedID [PMID 18439548OA-icon.png]
Condition C-reactive protein
Gene HNF1A
Risk Allele A
pValue 7.00E-017
OR 0.15
95% CI NR) mg/dl decreas




GWAS snp
PMID [PMID 21196492]
Trait
Title Genome-wide association study for C-reactive protein levels identified pleiotropic associations in the IL6 locus
Risk Allele G
P-val 3E-8
Odds Ratio 0.0700 [0.04-0.10] unit increase
GWAS snp
PMID [PMID 22001757OA-icon.png]
Trait
Title Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
Risk Allele G
P-val 7E-45
Odds Ratio 6.8000 None


[PMID 18439552OA-icon.png] Polymorphisms of the HNF1A gene encoding hepatocyte nuclear factor-1 alpha are associated with C-reactive protein.


[PMID 18852197OA-icon.png] Metabolic and cardiovascular traits: an abundance of recently identified common genetic variants.


[PMID 19197348OA-icon.png] Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae.


[PMID 19474294OA-icon.png] Potential etiologic and functional implications of genome-wide association loci for human diseases and traits.


[PMID 20031577OA-icon.png] Novel loci, including those related to Crohn disease, psoriasis, and inflammation, identified in a genome-wide association study of fibrinogen in 17 686 women: the Women's Genome Health Study.


[PMID 21195701] Effect of obesity on the association between common variations in the HNF1A gene region and C-reactive protein level in Taiwanese.


[PMID 21498636OA-icon.png] Genome-wide "pleiotropy scan" identifies HNF1A region as a novel pancreatic cancer susceptibility locus.


[PMID 21647738OA-icon.png] Genome-wide association with C-reactive protein levels in CLHNS: evidence for the CRP and HNF1A loci and their interaction with exposure to a pathogenic environment.


[PMID 22569176] MALDI-TOF mass spectrometry screening of cholelithiasis risk markers in the gene of HNF1alpha.


GET Evidence
rs7310409
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.612903
summary



[PMID 23092954OA-icon.png] SHAVE: shrinkage estimator measured for multiple visits increases power in GWAS of quantitative traits.


[PMID 23183503] Variants within HNF1alpha and ANGPTL4 genes and acute coronary syndrome in Czech population. The GENDEMIP study.


[PMID 24671014] Genetic risk assessment for cardiovascular disease with seven genes associated with plasma C-reactive protein concentrations in Asian populations