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rs733618

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(A;A) 0 normal
(A;G) 1.87x risk for myasthenia gravis
(G;G) normal
(T;T) 0
ReferenceGRCh38 38.1/141
Chromosome2
Position203866221
GeneCTLA4
is asnp
is mentioned by
dbSNPrs733618
ebirs733618
HLIrs733618
Exacrs733618
Varsomers733618
Maprs733618
PheGenIrs733618
hapmaprs733618
1000 genomesrs733618
hgdprs733618
ensemblrs733618
gopubmedrs733618
geneviewrs733618
scholarrs733618
googlers733618
pharmgkbrs733618
gwascentralrs733618
openSNPrs733618
23andMers733618
23andMe allrs733618
SNP Nexus

SNPshotrs733618
SNPdbers733618
MSV3drs733618
GWAS Ctlgrs733618
GMAF0.1708
Max Magnitude0
? (A;A) (A;G) (G;G) 28
rs733618, also known as T/C-1772, is a SNP in the upstream activator sequence of the cytotoxic T lymphocyte associated antigen-4 CTLA4 gene. This gene encodes the CD152 antigen.

A study of 165 Swedish myasthenia gravis patients concluded that the rs733618(A;G) heterozygotes had an odds ratio of 1.87 (CI: 1.01-3.49, p=0.049) for the disease compared to healthy individuals, yet neither allele on its own showed increased risk.[PMID 18088253]

[PMID 18059468] rs231775 (CTLA4_+49_G/A P=0.0219) and rs733618 (CTLA4_-1722_T/C P=0.0096) susceptibility to Graves' disease

Neighborrs11571316
Distance145
Neighborrs4553808
Distance61


[PMID 21513760] Association of CTLA4 gene polymorphisms with lymphatic filariasis in an East Malaysian population


[PMID 15452244OA-icon.png] Cytotoxic T-lymphocyte antigen 4 gene and recovery from hepatitis B virus infection.


[PMID 18528295OA-icon.png] Influence of cytotoxic T lymphocyte-associated antigen 4 (CTLA4) common polymorphisms on outcome in treatment of melanoma patients with CTLA-4 blockade.


[PMID 19264973OA-icon.png] Assessing the reproducibility of asthma candidate gene associations, using genome-wide data.


[PMID 19300490OA-icon.png] An African ancestry-specific allele of CTLA4 confers protection against rheumatoid arthritis in African Americans.


[PMID 19500380OA-icon.png] LD2SNPing: linkage disequilibrium plotter and RFLP enzyme mining for tag SNPs.


[PMID 19609446OA-icon.png] CTLA4 autoimmunity-associated genotype contributes to severe pulmonary tuberculosis in an African population.


[PMID 19622768OA-icon.png] CTLA4 variants, UV-induced tolerance, and risk of non-melanoma skin cancer.


[PMID 19956097OA-icon.png] Remapping the type I diabetes association of the CTLA4 locus.


[PMID 19956101OA-icon.png] Overview of the Rapid Response data.


[PMID 20018068OA-icon.png] A comparison of case-only designs for detecting gene x gene interaction in rheumatoid arthritis using genome-wide case-control data in Genetic Analysis Workshop 16.


[PMID 20557968] Association analysis of cytotoxic T-lymphocyte antigen 4 gene polymorphisms with primary biliary cirrhosis in Japanese patients.


[PMID 22288822OA-icon.png] A pilot study on cytotoxic T lymphocyte-4 gene polymorphisms in urinary schistosomiasis.


[PMID 22418270] Polymorphisms in cytotoxic T lymphocyte associated antigen-4 influence the rate of acute rejection after renal transplantation in 167 Chinese recipients.


[PMID 24015180OA-icon.png] CTLA4 Gene Polymorphisms Influence the Incidence of Infection after Renal Transplantation in Chinese Recipients


[PMID 23628397] Lack of association between CTLA-4 and PDCD1 polymorphisms and acute rejection in German liver transplant recipients


[PMID 23261408] -1722T/C polymorphism (rs733618) of CTLA-4 significantly associated with systemic lupus erythematosus (SLE): a comprehensive meta-analysis.


[PMID 23663310OA-icon.png] Investigating highly replicated asthma genes as candidate genes for allergic rhinitis.


[PMID 25900029] SNP-SNP interactions of immunity related genes involved into CD28/B7 pathway with susceptibility to invasive ductal carcinoma of the breast