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rs733722

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) no positive effect of AChE inhibitors for Alzheimer's patients
(C;T) some positive effect of AChE inhibitors for Alzheimer's patients
(T;T) largest positive effect of AChE inhibitors for Alzheimer's patients
ReferenceGRCh38 38.1/142
Chromosome10
Position49608897
GeneCHAT, SLC18A3
is asnp
is mentioned by
dbSNPrs733722
ebirs733722
HLIrs733722
Exacrs733722
Varsomers733722
Maprs733722
PheGenIrs733722
hapmaprs733722
1000 genomesrs733722
hgdprs733722
ensemblrs733722
gopubmedrs733722
geneviewrs733722
scholarrs733722
googlers733722
pharmgkbrs733722
gwascentralrs733722
openSNPrs733722
23andMers733722
23andMe allrs733722
SNP Nexus

SNPshotrs733722
SNPdbers733722
MSV3drs733722
GWAS Ctlgrs733722
GMAF0.2746
Max Magnitude
? (C;C) (C;T) (T;T) 28
rs733722, also known as -5293C>T, is a SNP near the choline acetyltransferase CHAT gene.

A study of 121 Alzheimer's disease patients treated primarily with the acetylcholinesterase (AChE) inhibitors donepezil or galantamine found different rates of mental decline depending on rs733722 genotypes. Individuals of rs733722(C;C) genotype effectively showed declines in cognition over time equivalent to untreated patients, whereas rs733722(C;T) individuals showed less decline, and rs733722(T;T) patients had a negligible decline over the course of the study (~15 months).[PMID 16424819]

An earlier study by these authors found no association between SNPs in this gene and actual risk for Alzheimer's.[PMID 12759818]


[PMID 18072279OA-icon.png] Combining fMRI and SNP data to investigate connections between brain function and genetics using parallel ICA.


[PMID 18165968OA-icon.png] Identification of pharmacogenetic markers in smoking cessation therapy.