Have questions? Visit https://www.reddit.com/r/SNPedia

rs735665

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(G;G) 0 common on affy axiom data
Make rs735665(A;A)
Make rs735665(A;G)
ReferenceGRCh38 38.1/141
Chromosome11
Position123490689
GeneGRAMD1B
is asnp
is mentioned by
dbSNPrs735665
ebirs735665
HLIrs735665
Exacrs735665
Varsomers735665
Maprs735665
PheGenIrs735665
hapmaprs735665
1000 genomesrs735665
hgdprs735665
ensemblrs735665
gopubmedrs735665
geneviewrs735665
scholarrs735665
googlers735665
pharmgkbrs735665
gwascentralrs735665
openSNPrs735665
23andMers735665
23andMe allrs735665
SNP Nexus

SNPshotrs735665
SNPdbers735665
MSV3drs735665
GWAS Ctlgrs735665
GMAF0.1074
Max Magnitude0
? (A;A) (A;G) (G;G) 28
23andMe blog chronic lymphocytic leukemia
  • rs735665 A 1.45

news Slager and colleagues validated these in an independent sample of patients. The strongest association was for rs735665 on 11q24, where the risk was 50 percent higher. This was closely followed by a 39 percent increased risk associated with rs9378805 on 6p25.

GWAS
SNP rs735665
PubMedID [PMID 18758461]
Condition Chronic lymphocytic leukemia
Gene GRAMD1B
Risk Allele A
pValue 4.00E-012
OR 1.45
95% CI 1.31-1.61


OMIM612559
DescLEUKEMIA, CHRONIC LYMPHOCYTIC SUSCEPTIBILITY TO, 5
Variant
Relatedalso
[PMID 20332261OA-icon.png] Genetic Susceptibility Variants for Chronic Lymphocytic Leukemia
GWAS snp
PMID [PMID 20639881OA-icon.png]
Trait Follicular lymphoma
Title Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32
Risk Allele T
P-val 4E-9
Odds Ratio 1.81 [1.50-2.20]


[PMID 20855867] Inherited genetic susceptibility to monoclonal B-cell lymphocytosis

[PMID 19620980OA-icon.png] Genetic variants at 6p21.33 are associated with susceptibility to follicular lymphoma.

[PMID 20731705OA-icon.png] Genetic susceptibility for chronic lymphocytic leukemia among Chinese in Hong Kong.

GWAS snp
PMID [PMID 22700719OA-icon.png]
Trait
Title Common variation at 6p21.31 (BAK1) influences the risk of chronic lymphocytic leukemia.
Risk Allele A
P-val 3E-12
Odds Ratio 1.5200 None


GET Evidence
rs735665
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.0859375
summary



GWAS snp
PMID [PMID 23770605OA-icon.png]
Trait Chronic lymphocytic leukemia
Title Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia.
Risk Allele A
P-val 4E-39
Odds Ratio 1.62 [NR]


[PMID 23455380] Risk of genome-wide association study-identified genetic variants for non-Hodgkin lymphoma in a Chinese population.

GWAS snp
PMID [PMID 24292274]
Trait Chronic lymphocytic leukemia
Title A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia.
Risk Allele A
P-val 4E-24
Odds Ratio 1.64 [NR]