|| common on affy axiom data
|| common in clinvar
[PMID 20522203] Age- and gender-specific association between ADA (22G>A) and TNF-alpha (-308G>A) genetic polymorphisms
[PMID 21865054] Age- and gender-specific epistasis between ADA and TNF-? influences human life-expectancy
[PMID 21734253] Functional ADA polymorphism increases sleep depth and reduces vigilant attention in humans.
|| Low clinical importance, Likely benign
|| This common variant is reported to reduce adenosine deaminase enzyme activity. It has been associated with an increased tendency for non-REM sleep -- more slow wave sleep, less nocturnal wakings, and a stronger negative impact of sleep deprivation. A role for this gene and variant was previously proposed for autism susceptibility, but this is controversial and was not replicated by later studies.
[PMID 24896148] The functional polymorphism rs73598374:G>A (p.Asp8Asn) of the ADA gene is associated with telomerase activity and leukocyte telomere length