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rs737280

From SNPedia

Orientationminus
Stabilizedminus
Make rs737280(A;A)
Make rs737280(A;G)
Make rs737280(G;G)
ReferenceGRCh38 38.1/141
Chromosome12
Position111757172
GeneACAD10
is asnp
is mentioned by
dbSNPrs737280
ebirs737280
HLIrs737280
Exacrs737280
Varsomers737280
Maprs737280
PheGenIrs737280
hapmaprs737280
1000 genomesrs737280
hgdprs737280
ensemblrs737280
gopubmedrs737280
geneviewrs737280
scholarrs737280
googlers737280
pharmgkbrs737280
gwascentralrs737280
openSNPrs737280
23andMers737280
23andMe allrs737280
SNP Nexus

SNPshotrs737280
SNPdbers737280
MSV3drs737280
GWAS Ctlgrs737280
Max Magnitude
? (A;A) (A;G) (G;G) 28

A 2014 publication reports that carriers of one or two copies of the "clade 2 haplotype", marked by the rs737280(G) allele of a SNP apparently tagging a haplotype of the adjacent ALDH2 gene, showed a 2- to 5-fold increase in Parkinson's disease risk when exposed to higher amounts of pesticide exposure. No such increase was seen in rs737280(A) individuals, and, independent of pesticide exposure, there was no association between rs737280 and risk for Parkinson's disease. This was a relatively small study, and given also the difference in rs737280 allele frequency between ethnic groups, it will be interesting to see if this study can be confirmed in larger, and different, populations.[PMID 24491970OA-icon.png]