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rs737865

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(A;G)
Make rs737865(C;C)
Make rs737865(C;T)
Make rs737865(T;T)
ReferenceGRCh38 38.1/141
Chromosome22
Position19942598
GeneCOMT, TXNRD2
is asnp
is mentioned by
dbSNPrs737865
ebirs737865
HLIrs737865
Exacrs737865
Varsomers737865
Maprs737865
PheGenIrs737865
hapmaprs737865
1000 genomesrs737865
hgdprs737865
ensemblrs737865
gopubmedrs737865
geneviewrs737865
scholarrs737865
googlers737865
pharmgkbrs737865
gwascentralrs737865
openSNPrs737865
23andMers737865
23andMe allrs737865
SNP Nexus

SNPshotrs737865
SNPdbers737865
MSV3drs737865
GWAS Ctlgrs737865
GMAF0.2392
Max Magnitude
? (C;C) (C;T) (T;T) 28
part of a three marker haplotype rs737865-rs4680-rs165599

COMT haplotypes at rs737865 and rs165599 may predict a favorable outcome for bupropion treatment for smoking cessation.

We have typed the IVS 1 rs737865 and 3' rs615599 sites and also included a novel IVS 1 indel polymorphism. We report that the schizophrenia-associated haplotype is significantly heterogeneous in populations worldwide. [PMID 15098000]

may affect non-Hodgkin lymphoma, anxiety-related personality traits

Also mentioned in these PMIDs


[PMID 19369177] Association of the 3' Region of COMT with Schizophrenia in Taiwan


[PMID 19290789] Association studies of catechol-O-methyltransferase (COMT) gene with schizophrenia and response to antipsychotic treatment


[PMID 19077118] Genetic variants in COMT and neurocognitive impairment in families of patients with schizophrenia

OMIM104300
DescALZHEIMER DISEASE; AD
Variant
Relatedalso
OMIM116790
DescCATECHOL-O-METHYLTRANSFERASE; COMT
Variant
Relatedalso




[PMID 21940152] The impact of COMT gene polymorphisms on suicidality in treatment resistant major depressive disorder - A European Multicenter Study


[PMID 12802784OA-icon.png] A haplotype implicated in schizophrenia susceptibility is associated with reduced COMT expression in human brain.


[PMID 15931594OA-icon.png] An entropy-based statistic for genomewide association studies.


[PMID 16027741] Catechol-O-methyltransferase haplotypes are associated with psychosis in Alzheimer disease.


[PMID 16232322OA-icon.png] COMT genetic variation confers risk for psychotic and affective disorders: a case control study.


[PMID 16483362OA-icon.png] The quantification of COMT mRNA in post mortem cerebellum tissue: diagnosis, genotype, methylation and expression.


[PMID 16525418] Association of the Val158Met catechol O-methyltransferase genetic polymorphism with panic disorder.


[PMID 16816420OA-icon.png] Nonlinear tests for genomewide association studies.


[PMID 16837108] Haplotypes in cathechol-O-methyltransferase gene confer increased risk for psychosis in Alzheimer disease.


[PMID 17363961] Clinical involvement of catechol-O-methyltransferase polymorphisms in schizophrenia spectrum disorders: influence on the severity of psychotic symptoms and on the response to neuroleptic treatment.


[PMID 17427186] Association analysis of COMT polymorphisms and schizophrenia in a Chinese Han population: a case-control study.


[PMID 17466074OA-icon.png] Genetic polymorphisms in dopamine-related genes and smoking cessation in women: a prospective cohort study.


[PMID 17482701] No associations exist between five functional polymorphisms in the catechol-O-methyltransferase gene and schizophrenia in a Japanese population.


[PMID 17630406OA-icon.png] Dopamine genes and schizophrenia: case closed or evidence pending?


[PMID 17707347OA-icon.png] Genetic variation in catechol-O-methyltransferase: effects on working memory in schizophrenic patients, their siblings, and healthy controls.


[PMID 18081002] Association of catechol-O-methyltransferase variants with loudness dependence of auditory evoked potentials.


[PMID 18384078] Association study of candidate variants of COMT with neuroticism, anxiety and depression.


[PMID 18436194OA-icon.png] Catechol-O-methyltransferase contributes to genetic susceptibility shared among anxiety spectrum phenotypes.


[PMID 18574484OA-icon.png] The complex global pattern of genetic variation and linkage disequilibrium at catechol-O-methyltransferase.


[PMID 18704099OA-icon.png] Association between the catechol-O-methyltransferase Val158Met polymorphism and cocaine dependence.


[PMID 18715757OA-icon.png] Genetic associations with schizophrenia: meta-analyses of 12 candidate genes.


[PMID 19071221OA-icon.png] Impact of interacting functional variants in COMT on regional gray matter volume in human brain.


[PMID 19329282] Meta-analysis of association between genetic variants in COMT and schizophrenia: an update.


[PMID 19365560OA-icon.png] Low enzymatic activity haplotypes of the human catechol-O-methyltransferase gene: enrichment for marker SNPs.


[PMID 19721400] Association between COMT gene and Chinese male schizophrenic patients with violent behavior.


[PMID 19911060OA-icon.png] Persistence criteria for susceptibility genes for schizophrenia: a discussion from an evolutionary viewpoint.


[PMID 20531207] The impact of catechol-O-methyltransferase SNPs and haplotypes on treatment response phenotypes in major depressive disorder: a case-control association study.


[PMID 20667552] Catechol-o-methyltransferase gene modulation on suicidal behavior and personality traits: review, meta-analysis and association study.


[PMID 21172166OA-icon.png] Pharmacogenetics of antidepressant response.


[PMID 21204206OA-icon.png] Evaluation of 64 candidate single nucleotide polymorphisms as risk factors for neural tube defects in a large Irish study population.


[PMID 21462137] [An association study of COMT gene polymorphisms with schizophrenia].


[PMID 21600957] COMT and age at onset in mood disorders: a replication and extension study.


[PMID 21656904OA-icon.png] Association between polymorphisms in catechol-O-methyltransferase (COMT) and cocaine-induced paranoia in European-American and African-American populations.


GET Evidence
rs737865
aa_change
aa_change_short
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.226562
summary



[PMID 24382678] Association between maternal COMT gene polymorphisms and fetal neural tube defects risk in a Chinese population


[PMID 22705295] Association of MB-COMT polymorphisms with schizophrenia-susceptibility and symptom severity in an African cohort.


[PMID 23178897OA-icon.png] The catechol-O-methyltransferase gene (COMT) and cognitive function from childhood through adolescence.


[PMID 23351565] Potential role of membrane-bound COMT gene polymorphisms in female depression vulnerability.


[PMID 23598060] Association study of polymorphisms in the alpha 7 nicotinic acetylcholine receptor subunit and catechol-o-methyl transferase genes with sensory gating in first-episode schizophrenia


[PMID 27228319] A Tetra-Primer Amplification Refractory System Technique for the Cost-Effective and Novel Genotyping of Eight Single-Nucleotide Polymorphisms of the Catechol-O-Methyltransferase Gene.