|| common in complete genomics
The derived allele of coding SNP rs73885319
(p.S342G) defines, together with the derived allele of coding SNP rs60910145
(p.I384M), the APOL1 G1 allele. This allele has been shown to associate with kidney disease while conferring protection against Trypanosoma brucei rhodesiense. 10.1126/science.1193032
] Missense mutations in the APOL1 gene are highly associated with end stage kidney disease risk previously attributed to the MYH9 gene.
|| not reviewed
|| Insufficiently evaluated not reviewed
[PMID 22956460] Genetic variation in APOL1 and MYH9 genes is associated with chronic kidney disease among Nigerians.
[PMID 25921719] APOL1 Genotype and Glomerular and Tubular Kidney Injury in Women With HIV
[PMID 26025194] APOL1 G1 genotype modifies the association between HDLC and kidney function in African Americans