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rs743554

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(C;C) 0 normal
(C;T) 2x higher ER- breast cancer risk
(T;T) 2x higher ER- breast cancer risk
ReferenceGRCh38 38.1/142
Chromosome17
Position75758167
GeneGALK1, ITGB4
is asnp
is mentioned by
dbSNPrs743554
ebirs743554
HLIrs743554
Exacrs743554
Varsomers743554
Maprs743554
PheGenIrs743554
hapmaprs743554
1000 genomesrs743554
hgdprs743554
ensemblrs743554
gopubmedrs743554
geneviewrs743554
scholarrs743554
googlers743554
pharmgkbrs743554
gwascentralrs743554
openSNPrs743554
23andMers743554
23andMe allrs743554
SNP Nexus

SNPshotrs743554
SNPdbers743554
MSV3drs743554
GWAS Ctlgrs743554
GMAF0.1373
Max Magnitude0
? (C;C) (C;T) (T;T) 28

[PMID 18550570] microRNA 749 Swedish incident breast cancer cases with detailed clinical data and up to 15 years of follow-up together with 1493 matched controls. The strongest association was between the rs743554(T) allele of the ITGB4 gene and estrogen receptor negative (ER-) tumors (odds ratio 2.09, CI: 1.19-3.67) and worse survival compared to the wild type genotype carriers (hazard ratio [HR] 2.11, CI: 1.21-3.68). The poor survival was significantly associated with the aggressive tumour characteristics: high grade, lymph node metastasis and high stage.

Neighborrs871443
Distance745
[PMID 19290790OA-icon.png] MicroRNA polymorphisms: the future of pharmacogenomics, molecular epidemiology and individualized medicine.