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rs744373

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(C;C) 2 1.17x risk of Alzheimer's
(C;T) 2 1.17x risk of Alzheimer's
(T;T) 1 Normal
ReferenceGRCh38 38.1/141
Chromosome2
Position127137039
is asnp
is mentioned by
dbSNPrs744373
ebirs744373
HLIrs744373
Exacrs744373
Varsomers744373
Maprs744373
PheGenIrs744373
hapmaprs744373
1000 genomesrs744373
hgdprs744373
ensemblrs744373
gopubmedrs744373
geneviewrs744373
scholarrs744373
googlers744373
pharmgkbrs744373
gwascentralrs744373
openSNPrs744373
23andMers744373
23andMe allrs744373
SNP Nexus

SNPshotrs744373
SNPdbers744373
MSV3drs744373
GWAS Ctlgrs744373
GMAF0.3714
Max Magnitude2
? (C;C) (C;T) (T;T) 28
rs6733839 and rs744373 are less than 2,000 base pairs apart,and they have similar ORs and MAFs. Therefore, it seems reasonable to suspect that these 2 SNPs are actually reporting the same signal.


[PMID 20460622OA-icon.png] Genome-wide analysis of genetic loci associated with Alzheimer's disease


[PMID 21321396OA-icon.png] Replication of BIN1 Association with Alzheimer's Disease and Evaluation of Genetic Interactions

GWAS snp
PMID [PMID 21390209OA-icon.png]
Trait
Title Meta-Analysis for Genome-Wide Association Study Identifies Multiple Variants at the BIN1 Locus Associated with Late-Onset Alzheimer's Disease
Risk Allele
P-val 1E-10
Odds Ratio 1.1900 [NR]
GWAS snp
PMID [PMID 21460840OA-icon.png]
Trait
Title Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease
Risk Allele
P-val 3E-14
Odds Ratio 1.1700 [1.12-1.21]
GWAS snp
PMID [PMID 21627779OA-icon.png]
Trait
Title The membrane-spanning 4-domains, subfamily A (MS4A) gene cluster contains a common variant associated with Alzheimer's disease.
Risk Allele
P-val 2E-9
Odds Ratio 1.1800 [NR]


[PMID 19734902OA-icon.png] Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease.


[PMID 21220176] Evidence of the association of BIN1 and PICALM with the AD risk in contrasting European populations.


[PMID 21347408OA-icon.png] Fine mapping of genetic variants in BIN1, CLU, CR1 and PICALM for association with cerebrospinal fluid biomarkers for Alzheimer's disease.


[PMID 21379329OA-icon.png] Genome-wide association of familial late-onset Alzheimer's disease replicates BIN1 and CLU and nominates CUGBP2 in interaction with APOE.


[PMID 23419238OA-icon.png] Allele-specific polymerase chain reaction for the detection of Alzheimer's disease-related single nucleotide polymorphisms


[PMID 23570733] BIN1 gene rs744373 polymorphism contributes to Alzheimer's disease in East Asian population


[PMID 24260488OA-icon.png] Epistatic Genetic Effects among Alzheimer's Candidate Genes


[PMID 22005930OA-icon.png] Genome-wide association study of Alzheimer's disease with psychotic symptoms.


[PMID 22430674OA-icon.png] Genome-wide haplotype association study identifies the FRMD4A gene as a risk locus for Alzheimer's disease.


[PMID 23180304] Genetic risk score predicting accelerated progression from mild cognitive impairment to Alzheimer's disease.


[PMID 26680604] Polygenic Analysis of Late-Onset Alzheimer's Disease from Mainland China.