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rs749292

From SNPedia

Orientationplus
Stabilizedplus
Make rs749292(A;A)
Make rs749292(A;G)
Make rs749292(G;G)
ReferenceGRCh38 38.1/141
Chromosome15
Position51266534
GeneCYP19A1
is asnp
is mentioned by
dbSNPrs749292
ebirs749292
HLIrs749292
Exacrs749292
Varsomers749292
Maprs749292
PheGenIrs749292
hapmaprs749292
1000 genomesrs749292
hgdprs749292
ensemblrs749292
gopubmedrs749292
geneviewrs749292
scholarrs749292
googlers749292
pharmgkbrs749292
gwascentralrs749292
openSNPrs749292
23andMers749292
23andMe allrs749292
SNP Nexus

SNPshotrs749292
SNPdbers749292
MSV3drs749292
GWAS Ctlgrs749292
GMAF0.4307
Max Magnitude
? (A;A) (A;G) (G;G) 28
[PMID 18667686OA-icon.png] rs749292(A) associated with ovarian cancer risk in a codominant model for all races combined [AG versus AA genotype: odds ratio (OR), 1.48 and 95% confidence interval (CI), 1.07-2.04); GG versus AA: OR, 1.87 (CI, 1.24-2.82); Ptrend =0.002].

[PMID 19124504OA-icon.png] endometrial cancer

  • rs749292(A) allele OR of 1.14, 95% confidence interval of 1.09-1.21, and P = 7.1 x 10(-7)
  • rs727479(A) odds ratio per allele of 1.08, 95% confidence interval of 1.02-1.14, and P = 0.009
OMIM107910
DescCYTOCHROME P450, FAMILY 19, SUBFAMILY A, POLYPEPTIDE 1; CYP19A1
Variant
Relatedalso
[PMID 19789370OA-icon.png] CYP19A1 Genetic Variation in Relation to Prostate Cancer Risk and Circulating Sex Hormone Concentrations in Men from the Breast and Prostate Cancer Cohort Consortium


[PMID 16733710OA-icon.png] Association analyses of CYP19 gene polymorphisms with height variation in a large sample of Caucasian nuclear families.


[PMID 16782804OA-icon.png] Polymorphisms of estrogen-biosynthesis genes CYP17 and CYP19 may influence age at menarche: a genetic association study in Caucasian females.


[PMID 16949385] Aromatase gene (CYP 19) polymorphisms and endogenous androgen concentrations in a multiracial/multiethnic, multisite study of women at midlife.


[PMID 16949394] Cognitive functioning and sex steroid hormone gene polymorphisms in women at midlife.


[PMID 17002564OA-icon.png] Robust and comprehensive analysis of 20 osteoporosis candidate genes by very high-density single-nucleotide polymorphism screen among 405 white nuclear families identified significant association and gene-gene interaction.


[PMID 17325027] Genetic variation at the CYP19A1 locus predicts circulating estrogen levels but not breast cancer risk in postmenopausal women.


[PMID 18199708OA-icon.png] Haplotype analyses of CYP19A1 gene variants and breast cancer risk: results from the Shanghai Breast Cancer Study.


[PMID 18622258OA-icon.png] Association of genetic polymorphisms in CYP19A1 and blood levels of sex hormones among postmenopausal Chinese women.


[PMID 18941913OA-icon.png] Coffee intake, variants in genes involved in caffeine metabolism, and the risk of epithelial ovarian cancer.


[PMID 19015200OA-icon.png] Polymorphisms in estrogen- and androgen-metabolizing genes and the risk of gastric cancer.


[PMID 19064562OA-icon.png] Genetic variation in CYP19A1 and risk of breast cancer and fibrocystic breast conditions among women in Shanghai, China.


[PMID 19630952OA-icon.png] Sex steroid metabolism polymorphisms and mammographic density in pre- and early perimenopausal women.


[PMID 23129173OA-icon.png] Plasma estrone sulfate concentrations and genetic variation at the CYP19A1 locus in postmenopausal women with early breast cancer treated with letrozole


[PMID 26463708] Association of Variants in Candidate Genes with Lipid Profiles in Women with Early Breast Cancer on Adjuvant Aromatase Inhibitor Therapy