|(C;C)||0||common in clinvar|
A study has shown that inheriting the Cys version encoded by the corresponding SNP results in impaired (lower) lactonase activity; this may (or may not) lead to problems with innate immunity, atherosclerosis, and other diseases.[PMID 19840942][PMID 22016051] Leads from xenobiotic metabolism genes for Parkinson's disease among north Indians
|Disease||PARAOXONASE 2 POLYMORPHISM|
|CLNDBN||PARAOXONASE 2 POLYMORPHISM|
|CLNSRC||OMIM Allelic Variant|
[PMID 17601350] A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition.
[PMID 18513389] New application of intelligent agents in sporadic amyotrophic lateral sclerosis identifies unexpected specific genetic background.
[PMID 19104460] Interaction between PON1 and population density in amyotrophic lateral sclerosis.
[PMID 19131662] A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.
[PMID 19321847] A large-scale international meta-analysis of paraoxonase gene polymorphisms in sporadic ALS.
[PMID 19379518] Development of a fingerprinting panel using medically relevant polymorphisms.
[PMID 19546579] Evaluation of polymorphisms in paraoxonase 2 (PON2) gene and their association with cardiovascular-renal disease risk in Mexican Americans.
[PMID 19587357] A systematic meta-analysis of genetic association studies for diabetic retinopathy.
[PMID 20056567] Childhood brain tumors, residential insecticide exposure, and pesticide metabolism genes.
[PMID 20381198] Lack of association of PON polymorphisms with sporadic ALS in an Italian population.
[PMID 20565774] Population based allele frequencies of disease associated polymorphisms in the Personalized Medicine Research Project.
[PMID 21223581] Association analysis of PON2 genetic variants with serum paraoxonase activity and systemic lupus erythematosus.
[PMID 21231776] C-reactive protein levels are associated with paraoxonase polymorphism L55M in patients undergoing cardiac SPECT imaging.
|qualified_impact||Insufficiently evaluated not reviewed|
[PMID 22877234] Polymorphisms in genes involved in oxidative stress response in patients with sudden sensorineural hearing loss and Meniere's disease in a Japanese population.
[PMID 22884547] Association analysis of PON polymorphisms in sporadic ALS in a Chinese population.
[PMID 23327886] Association between paraoxonase 2 gene polymorphisms and noise-induced hearing loss in the Chinese population.
[PMID 24100645] Association of paraoxonase gene polymorphisms with diabetic nephropathy and retinopathy
[PMID 24148949] [Association between single nucleotide polymorphisms of PON2 gene and susceptibility to occupational noise-induced deafness among Chinese Han population exposed to high noise levels]