|Trait||Body mass index|
|Title||Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity|
|Odds Ratio||3.63 [2.49-4.77] % SD|
|Trait||Body mass index|
|Title||Six new loci associated with body mass index highlight a neuronal influence on body weight regulation|
|Odds Ratio||0.15 [0.08-0.21] kg/m2 increase|
[PMID 20386550] Genes and lifestyle factors in obesity: results from 12 462 subjects from MONICA/KORA
[PMID 21796141] Computed tomography analysis of the association between the SH2B1 rs7498665 single-nucleotide polymorphism and visceral fat area
[PMID 21912638] Studies of metabolic phenotypic correlates of 15 obesity associated gene variants
[PMID 21907990] The SH2B1 obesity locus is associated with myocardial infarction in diabetic patients and with NO synthase activity in endothelial cells
[PMID 22248999] Replication of the SH2B1 rs7498665 association with obesity in a Belgian study population
[PMID 22083549] Study of eight GWAS-identified common variants for association with obesity-related indices in Chinese children at puberty
[PMID 17228025] The SH2B gene is associated with serum leptin and body fat in normal female twins.
[PMID 19478790] The role of obesity-associated loci identified in genome-wide association studies in the determination of pediatric BMI.
[PMID 19526209] Is the thrifty genotype hypothesis supported by evidence based on confirmed type 2 diabetes- and obesity-susceptibility variants?
[PMID 19553259] Common body mass index-associated variants confer risk of extreme obesity.
[PMID 19910938] Novel obesity risk loci do not determine distribution of body fat depots: a whole-body MRI/MRS study.
[PMID 20127379] From monogenic to polygenic obesity: recent advances.
[PMID 20369022] Candidate causal regulatory effects by integration of expression QTLs with complex trait genetic associations.
[PMID 20712903] Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study.
[PMID 20725061] MC4R variant is associated with BMI but not response to resistance training in young females.
[PMID 20824172] Physical activity attenuates the genetic predisposition to obesity in 20,000 men and women from EPIC-Norfolk prospective population study.
[PMID 21283731] FTO and MC4R gene variants are associated with obesity in polycystic ovary syndrome.
|qualified_impact||Insufficiently evaluated pharmacogenetic|
[PMID 23270367] Mutation screen in the GWAS derived obesity gene SH2B1 including functional analyses of detected variants
[PMID 23519644] Analyses of Non-Synonymous Obesity Risk Alleles in SH2B1 (rs7498665) and APOB48R (rs180743) in Obese Children and Adolescents Undergoing a 1-year Lifestyle Intervention
|Title||Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.|
|Odds Ratio||1.07 [NR]|
[PMID 24621099] Meta-analyses between 18 candidate genetic markers and overweight/obesity
[PMID 23640704] Common variants near BDNF and SH2B1 show nominal evidence of association with snacking behavior in European populations