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rs7501939

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(T;C)
Make rs7501939(C;C)
Make rs7501939(C;T)
Make rs7501939(T;T)
ReferenceGRCh38 38.1/141
Chromosome17
Position37741165
GeneHNF1B
is asnp
is mentioned by
dbSNPrs7501939
ebirs7501939
HLIrs7501939
Exacrs7501939
Varsomers7501939
Maprs7501939
PheGenIrs7501939
hapmaprs7501939
1000 genomesrs7501939
hgdprs7501939
ensemblrs7501939
gopubmedrs7501939
geneviewrs7501939
scholarrs7501939
googlers7501939
pharmgkbrs7501939
gwascentralrs7501939
openSNPrs7501939
23andMers7501939
23andMe allrs7501939
SNP Nexus

SNPshotrs7501939
SNPdbers7501939
MSV3drs7501939
GWAS Ctlgrs7501939
GMAF0.3861
Max Magnitude
? (C;C) (C;T) (T;T) 28

[1] related to Prostate cancer and Type-2 diabetes

[PMID 18701471OA-icon.png] The increased risk associated with rs7501939 and the closely linked rs4430796 is approximately doubled in individuals hereditarily predisposed to develop early-onset prostate cancer, based on a study of ~1,000 men.

[PMID 19998368OA-icon.png] rs7501939 identified as one of three HNF1B gene SNPs associated with decreased risk for prostate cancer in two large prospective studies

cancer-genetics these SNPs influence genetic risk for prostate cancer

GWAS snp
PMID [PMID 18264097]
Trait Prostate cancer
Title Multiple newly identified loci associated with prostate cancer susceptibility
Risk Allele C
P-val 8.9999999999999996E-12
Odds Ratio 1.41 [NR]
OMIM611955
DescPROSTATE CANCER, HEREDITARY, 11; HPC11
Variant
Relatedalso
GWAS snp
PMID [PMID 19767753OA-icon.png]
Trait Prostate cancer
Title Identification of seven new prostate cancer susceptibility loci through a genome-wide association study
Risk Allele C
P-val 3E-18
Odds Ratio NR NR
GWAS snp
PMID [PMID 20676098]
Trait
Title Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population
Risk Allele
P-val 1E-12
Odds Ratio None None
GWAS snp
PMID [PMID 21743057OA-icon.png]
Trait
Title Genome-wide association study identifies new prostate cancer susceptibility loci.
Risk Allele C
P-val 0.000002
Odds Ratio 1.1900 [1.11-1.28]


[PMID 22299039OA-icon.png] HNF1B and Endometrial Cancer Risk: Results from the PAGE study


[PMID 18426861OA-icon.png] Association analysis of type 2 diabetes Loci in type 1 diabetes.


[PMID 18974127OA-icon.png] Association study of prostate cancer susceptibility variants with risks of invasive ovarian, breast, and colorectal cancer.


[PMID 19096518OA-icon.png] Novel association of HK1 with glycated hemoglobin in a non-diabetic population: a genome-wide evaluation of 14,618 participants in the Women's Genome Health Study.


[PMID 19168595OA-icon.png] Common variants of hepatocyte nuclear factor 1beta are associated with type 2 diabetes in a Chinese population.


[PMID 19401414OA-icon.png] Confirmation of multiple risk Loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population.


[PMID 19455305OA-icon.png] No association of multiple type 2 diabetes loci with type 1 diabetes.


[PMID 20509872OA-icon.png] Implication of genetic variants near SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, FTO, TCF2, KCNQ1, and WFS1 in type 2 diabetes in a Chinese population.


[PMID 20690139] Meta-analysis of genome-wide and replication association studies on prostate cancer.


[PMID 21278902OA-icon.png] Genetic risk profiling for prediction of type 2 diabetes.


[PMID 21390317OA-icon.png] Characterizing associations and SNP-environment interactions for GWAS-identified prostate cancer risk markers--results from BPC3.


GET Evidence
rs7501939
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.608333
summary



[PMID 24422606] Assessment of Association between Common Variants at 17q12 and Prostate Cancer Risk-Evidence from Serbian Population and Meta-Analysis


[PMID 27437873] A common variant within the HNF1B gene is associated with overall survival of multiple myeloma patients: Results from the IMMEnSE consortium and meta-analysis.