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rs7524102

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 0 common in complete genomics
Make rs7524102(A;G)
Make rs7524102(G;G)
ReferenceGRCh38 38.1/141
Chromosome1
Position22371954
GeneZBTB40
is asnp
is mentioned by
dbSNPrs7524102
ebirs7524102
HLIrs7524102
Exacrs7524102
Varsomers7524102
Maprs7524102
PheGenIrs7524102
hapmaprs7524102
1000 genomesrs7524102
hgdprs7524102
ensemblrs7524102
gopubmedrs7524102
geneviewrs7524102
scholarrs7524102
googlers7524102
pharmgkbrs7524102
gwascentralrs7524102
openSNPrs7524102
23andMers7524102
23andMe allrs7524102
SNP Nexus

SNPshotrs7524102
SNPdbers7524102
MSV3drs7524102
GWAS Ctlgrs7524102
GMAF0.2259
Max Magnitude0
? (A;A) (A;G) (G;G) 28
Rs7524102
PubMed [PMID 18445777]
Affy Probeset SNP_A-2092875
Affy Orientation same
On GW 5.0
Alleles A/B /
Ancestral G
Population Caucasian
Allele A
Case Freq.
Control Freq.
Odds Ratio Het
Odds Ratio Hom
Odds Ratio All -
Disease Bone mineral density, lower (BMD-L)


rs7524102 increases susceptibility to Bone mineral density variations, lower for carriers of the A allele [PMID 18445777]

rs7524102 increases susceptibility to Osteoporotic fractures 1.12 times for carriers of the A allele [PMID 18445777]

GWAS
SNP rs7524102
PubMedID [PMID 18445777]
Condition Bone mineral density (spine)
Gene ZBTB40
Risk Allele A
pValue 9.00E-009
OR 0.11
95% CI 0.07-0.15) SD decreas


GWAS snp
PMID [PMID 19079262]
Trait Bone mineral density (hip)
Title New sequence variants associated with bone mineral density
Risk Allele A
P-val 1E-16
Odds Ratio 0.15 [0.11-0.18] SD decrease
OMIM606928
DescBONE MINERAL DENSITY QUANTITATIVE TRAIT LOCUS 3; BMND3
Variant
Relatedalso
OMIM612106
DescZINC FINGER- AND BTB DOMAIN-CONTAINING PROTEIN 40; ZBTB40
Variant
Relatedalso
GWAS snp
PMID [PMID 19801982OA-icon.png]
Trait Bone mineral density (spine)
Title Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies
Risk Allele G
P-val 3E-10
Odds Ratio 0.09 [0.06-0.12] sd increase


GWAS snp
PMID [PMID 19915572OA-icon.png]
Trait Ulcerative colitis
Title Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region
Risk Allele A
P-val 3E-7
Odds Ratio 1.10 [1.00-1.21]



GWAS snp
PMID [PMID 21297633OA-icon.png]
Trait
Title Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47
Risk Allele A
P-val 2E-13
Odds Ratio 1.1000 [1.05-1.16]
GWAS snp
PMID [PMID 21533022OA-icon.png]
Trait
Title Genome-wide association study using extreme truncate selection identifies novel genes affecting bone mineral density and fracture risk.
Risk Allele G
P-val 9E-7
Odds Ratio 0.4400 [NR] unit decrease
GWAS snp
PMID [PMID 21732829]
Trait
Title Wnt signaling and Dupuytren's disease.
Risk Allele G
P-val 3E-9
Odds Ratio 1.2800 None


[PMID 22824048] Opposite associations of osteoprotegerin and ZBTB40 polymorphisms with bone mineral density of the hip in postmenopausal Taiwanese women

[PMID 19181680OA-icon.png] Common variants in the region around Osterix are associated with bone mineral density and growth in childhood.

[PMID 19629617OA-icon.png] Replication study of candidate genes/loci associated with osteoporosis based on genome-wide screening.

[PMID 20534768OA-icon.png] OPG and RANK polymorphisms are both associated with cortical bone mineral density: findings from a metaanalysis of the Avon longitudinal study of parents and children and gothenburg osteoporosis and obesity determinants cohorts.

[PMID 20554715] Analysis of recently identified osteoporosis susceptibility genes in Han Chinese women.


GET Evidence
rs7524102
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.277778
summary