Have questions? Visit https://www.reddit.com/r/SNPedia

rs7539542

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) 0.51x decreased breast cancer risk
(C;G) 0.59x decreased breast cancer risk
(G;G) normal
ReferenceGRCh38 38.1/141
Chromosome1
Position202940846
GeneADIPOR1
is asnp
is mentioned by
dbSNPrs7539542
ebirs7539542
HLIrs7539542
Exacrs7539542
Varsomers7539542
Maprs7539542
PheGenIrs7539542
hapmaprs7539542
1000 genomesrs7539542
hgdprs7539542
ensemblrs7539542
gopubmedrs7539542
geneviewrs7539542
scholarrs7539542
googlers7539542
pharmgkbrs7539542
gwascentralrs7539542
openSNPrs7539542
23andMers7539542
23andMe allrs7539542
SNP Nexus

SNPshotrs7539542
SNPdbers7539542
MSV3drs7539542
GWAS Ctlgrs7539542
GMAF0.4986
Max Magnitude
? (C;C) (C;G) (G;G) 28
A study of 733 breast cancer cases for 10 SNPs concluded that a rs7539542 genotype was associated with decreased risk (odds ratio 0.51, CI: 0.28-0.92).[PMID 18451143OA-icon.png]

After categorizing individuals by adiponectin signaling status, this study found that compared with high signalers, intermediate signalers had a 4.16-fold increase in breast cancer risk (CI: 0.49-35.19), and low signalers had a 6.56x higher breast cancer risk (CI: 0.78-54.89, p(trend) = 0.001).[PMID 18451143OA-icon.png]

Adiponectin signaling status was assigned as follows:

rs1501299(G,G) + rs2241766(T,T) = low signaler
rs1501299(G,T) + rs2241766(T,T) = low signaler
rs1501299(G,G) + rs2241766(G,T) = low signaler
rs1501299(T,T) + rs2241766(T,T) = intermediate signaler
rs1501299(G,T) + rs2241766(G,T) = intermediate signaler
rs1501299(G,G) + rs2241766(G,G) = intermediate signaler
rs1501299(G,T) + rs2241766(G,G) = high signaler
rs1501299(T,T) + rs2241766(G,G) = high signaler
rs1501299(T,T) + rs2241766(G,T) = high signaler


[PMID 21397927OA-icon.png] Polymorphisms of ADIPOQ and ADIPOR1 and prostate cancer risk


[PMID 16724230] Association of sequence variations in the gene encoding adiponectin receptor 1 (ADIPOR1) with body size and insulin levels. The Finnish Diabetes Prevention Study.


[PMID 16955209] Association between variants in the genes for adiponectin and its receptors with insulin resistance syndrome (IRS)-related phenotypes in Mexican Americans.


[PMID 17216283OA-icon.png] Adiponectin receptor genes: mutation screening in syndromes of insulin resistance and association studies for type 2 diabetes and metabolic traits in UK populations.


[PMID 18827209OA-icon.png] Variants of the adiponectin (ADIPOQ) and adiponectin receptor 1 (ADIPOR1) genes and colorectal cancer risk.


[PMID 19037660OA-icon.png] The association of SNPs in ADIPOQ, ADIPOR1, and ADIPOR2 with insulin sensitivity in a cohort of adolescents and their parents.


[PMID 27899942] Adiponectin receptor 1 and small ubiquitin-like modifier 4 polymorphisms are associated with risk of coronary artery disease without diabetes.