Several CVD risk variants were identified: In women, the combination of F5 rs7542281 Ã— THBD rs1042580, together with three single F5 SNPs, was associated with CVD events. Among men, PROC rs1041296, when combined with either ICAM1 rs5030341 or F5 rs2269648, was associated with total mortality. As a single variant, PROC rs1401296, together with the F5 Leiden mutation, was associated with ischemic stroke events.[PMID 17677000]
[PMID 18974842] Gender differences in genetic risk profiles for cardiovascular disease.