|Trait||Body mass index|
|Title||Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity|
|Odds Ratio||6.12 [4.69-7.55] % SD|
[PMID 19851340] Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population
[PMID 21625854] Implication of genetic variants near TMEM18, BCDIN3D/FAIM2, and MC4R with coronary artery disease and obesity in Chinese: a angiography-based study
[PMID 21912638] Studies of metabolic phenotypic correlates of 15 obesity associated gene variants
[PMID 19478790] The role of obesity-associated loci identified in genome-wide association studies in the determination of pediatric BMI.
[PMID 20127379] From monogenic to polygenic obesity: recent advances.
[PMID 20380707] The obesity gene, TMEM18, is of ancient origin, found in majority of neuronal cells in all major brain regions and associated with obesity in severely obese children.
[PMID 20712903] Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study.
[PMID 24670271] Association study of common polymorphisms in MSRA, TFAP2B, MC4R, NRXN3, PPARGC1A, TMEM18, SEC16B, HOXB5 and OLFM4 genes with obesity-related traits among Portuguese children.
|qualified_impact||Insufficiently evaluated pathogenic|
[PMID 23860325] Polymorphisms in FTO and near TMEM18 associate with type 2 diabetes and predispose to younger age at diagnosis of diabetes
[PMID 24348519] EMR-linked GWAS study: investigation of variation landscape of loci for body mass index in children