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rs7582658

From SNPedia

Orientationplus
Stabilizedplus
Make rs7582658(A;A)
Make rs7582658(A;G)
Make rs7582658(G;G)
ReferenceGRCh38 38.1/141
Chromosome2
Position188083114
is asnp
is mentioned by
dbSNPrs7582658
ebirs7582658
HLIrs7582658
Exacrs7582658
Varsomers7582658
Maprs7582658
PheGenIrs7582658
hapmaprs7582658
1000 genomesrs7582658
hgdprs7582658
ensemblrs7582658
gopubmedrs7582658
geneviewrs7582658
scholarrs7582658
googlers7582658
pharmgkbrs7582658
gwascentralrs7582658
openSNPrs7582658
23andMers7582658
23andMe allrs7582658
SNP Nexus

SNPshotrs7582658
SNPdbers7582658
MSV3drs7582658
GWAS Ctlgrs7582658
GMAF0.472
Max Magnitude
? (A;A) (A;G) (G;G) 28

This SNP was identified as a "core" SNP helping to define one (of nine total) runs of homozygosity (ROH) potentially associated with increased risk for schizophrenia. Each region consists of at least 100 consecutive SNPs, generally spanning 500KB or more, for which both chromosomes in an individual were homozygous. The overall odds ratio for schizophrenia associated with inheriting 1, 2, or 3 of these 9 ROHs was calculated to be 3.3, 5.4, or 24, respectively, with 95% confidence intervals of (1.9-5.7), (3.7-16.1), and (6.9-83.9), respectively.[PMID 18077426OA-icon.png]

This particular SNP, rs7582658, was deemed to be the core SNP of a region on chromosome 2 with 274 SNPs spanning 2282KB from 2:188489676 to 2:190772106 (build 35). Potentially independent of the ROH, the risk allele for this SNP in the orientation as displayed in HapMap v21a is (G).[PMID 18077426OA-icon.png]