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rs760805

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 2x increased risk for bladder cancer
(A;T) increased risk for bladder cancer if part of risk haplotype
(T;T) normal
ReferenceGRCh38 38.1/141
Chromosome1
Position24925432
GeneRUNX3
is asnp
is mentioned by
dbSNPrs760805
ebirs760805
HLIrs760805
Exacrs760805
Varsomers760805
Maprs760805
PheGenIrs760805
hapmaprs760805
1000 genomesrs760805
hgdprs760805
ensemblrs760805
gopubmedrs760805
geneviewrs760805
scholarrs760805
googlers760805
pharmgkbrs760805
gwascentralrs760805
openSNPrs760805
23andMers760805
23andMe allrs760805
SNP Nexus

SNPshotrs760805
SNPdbers760805
MSV3drs760805
GWAS Ctlgrs760805
GMAF0.4229
Max Magnitude
? (A;A) (A;T) (T;T) 28
rs760805, a SNP in the RUNX3 gene, has been reported to be the most significantly associated with risk for bladder cancer of several SNPs in this gene, based on a study of 368 Chinese patients. The adjusted odds ratio for the rs760805(A;A) genotype is 1.97 (CI: 1.44-2.69).[PMID 18684727]

Further investigation of this region in this same study indicated that 4 other SNPs in the RUNX3 gene, as well as smoking, are associated with increased risk for bladder cancer. In particular, 2 haplotypes, both containing the rs760805(A) allele, were associated with 2-3x increased risk. An individual carrying the risk forms of all 5 RUNX3 SNPs and also smoking had on average an odds ratio for bladder cancer that was 6.37 fold higher than average (CI: 4.57-8.87, p = 7.03 x 10(-28)).[PMID 18684727]


[PMID 19552756] Genetic variants in the Runt-related transcription factor 3 gene contribute to gastric cancer risk in a Chinese population

[PMID 19728008] Significant association of RUNX3 T/A polymorphism at intron 3 (rs760805) with the risk of gastric atrophy in Helicobacter pylori seropositive Japanese