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rs763110

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) 0 normal
(C;T) 2 ~0.80x reduced cancer risk
(T;T) 2 ~0.80x reduced cancer risk
ReferenceGRCh38 38.1/141
Chromosome1
Position172658358
GeneFASLG
is asnp
is mentioned by
dbSNPrs763110
ebirs763110
HLIrs763110
Exacrs763110
Varsomers763110
Maprs763110
PheGenIrs763110
hapmaprs763110
1000 genomesrs763110
hgdprs763110
ensemblrs763110
gopubmedrs763110
geneviewrs763110
scholarrs763110
googlers763110
pharmgkbrs763110
gwascentralrs763110
openSNPrs763110
23andMers763110
23andMe allrs763110
SNP Nexus

SNPshotrs763110
SNPdbers763110
MSV3drs763110
GWAS Ctlgrs763110
GMAF0.4311
Max Magnitude2
? (C;C) (C;T) (T;T) 28
rs763110, also known as -844C>T, is a SNP in the FAS ligand FASLG gene.

A meta-analysis of 19 published studies, including 11,105 cancer cases and 11,372 controls, concluded that the rs763110(C;T) and (T;T) genotypes were associated with a significantly reduced (about 0.80x) cancer risk of all cancer types.[PMID 19337311OA-icon.png]


[PMID 19240174] Polymorphisms in the FAS and FASL genes and survival of early stage non-small cell lung cancer.


[PMID 21807637] A Polymorphic -844T/C in FasL Promoter Predicts Survival and Relapse in Non-Small Cell Lung Cancer


[PMID 22732091] FASL -844 T/C polymorphism: A biomarker of good prognosis of breast cancer in the Tunisian population


ClinVar
Risk rs763110(T;T)
Alt rs763110(T;T)
Reference rs763110(C;C)
Significance Other
Disease LUNG CANCER
Variation info
Gene FASLG
CLNDBN LUNG CANCER, SUSCEPTIBILITY TO
Reversed 0
HGVS NC_000001.10:g.172627498C\x3d
CLNSRC OMIM Allelic Variant
CLNACC RCV000017960.3,



[PMID 18757527OA-icon.png] Apoptosis gene polymorphisms, age, smoking and the risk of non-small cell lung cancer.


[PMID 18759263OA-icon.png] Features associated with, and the impact of, hemolytic anemia in patients with systemic lupus erythematosus: LX, results from a multiethnic cohort.


[PMID 18805939OA-icon.png] Functional genetic polymorphisms and female reproductive disorders: part II--endometriosis.


[PMID 18854777OA-icon.png] Germline genetic variations in drug action pathways predict clinical outcomes in advanced lung cancer treated with platinum-based chemotherapy.


[PMID 19941645OA-icon.png] Fas and FasL gene polymorphisms are not associated with cervical cancer but differ among Black and Mixed-ancestry South Africans.


[PMID 20438363] Fas and FasL polymorphisms are not associated with acute myeloid leukemia risk in Koreans.


[PMID 20959405] The IFNG (IFN-gamma) genotype predicts cytogenetic and molecular response to imatinib therapy in chronic myeloid leukemia.


[PMID 15937082OA-icon.png] Functional polymorphisms in cell death pathway genes FAS and FASL contribute to risk of lung cancer.


[PMID 23141929] A Controlled Case Study of the Relationship Between Environmental Risk Factors and Apoptotic Gene Polymorphism and Lumbar Disc Herniation


[PMID 23392773] Apoptosis-related Fas and FasL gene polymorphisms' associations with knee osteoarthritis


[PMID 24086353OA-icon.png] FASL rs763110 Polymorphism Contributes to Cancer Risk: An Updated Meta-Analysis Involving 43,295 Subjects


[PMID 24424626] Association of genetic variants in apoptosis genes FAS and FASL with radiation-induced late toxicity after prostate cancer radiotherapy


[PMID 24587306OA-icon.png] Death Receptor (DR4) Haplotypes Are Associated with Increased Susceptibility of Gallbladder Carcinoma in North Indian Population


[PMID 23749041] Relation of the Fas and FasL gene polymorphisms with susceptibility to and severity of rheumatoid arthritis.


[PMID 25645050] Association between the CTLA-4, CD226, FAS polymorphisms and rheumatoid arthritis susceptibility: A meta-analysis


[PMID 25661359] The association between the SNP rs763110 and the risk of gynecological cancer: A meta-analysis


[PMID 26891954] Significant association between FasL gene -844T/C polymorphism and risk to hepatocellular carcinoma in Egyptian patients.


[PMID 26905515] Fas/FasL, Bcl2 and Caspase-8 gene polymorphisms in Chinese patients with rheumatoid arthritis.