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rs763317

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 3.5x increased lung cancer risk for never-smoking females
(A;G) increased lung cancer risk for never-smoking females
(G;G) 0 normal
ReferenceGRCh38 38.1/141
Chromosome7
Position55027504
GeneEGFR
is asnp
is mentioned by
dbSNPrs763317
ebirs763317
HLIrs763317
Exacrs763317
Varsomers763317
Maprs763317
PheGenIrs763317
hapmaprs763317
1000 genomesrs763317
hgdprs763317
ensemblrs763317
gopubmedrs763317
geneviewrs763317
scholarrs763317
googlers763317
pharmgkbrs763317
gwascentralrs763317
openSNPrs763317
23andMers763317
23andMe allrs763317
SNP Nexus

SNPshotrs763317
SNPdbers763317
MSV3drs763317
GWAS Ctlgrs763317
GMAF0.3485
Max Magnitude0
? (A;A) (A;G) (G;G) 28
rs763317, also known as 8227A>G, is a SNP located in the first intron of the epidermal growth factor receptor EGFR gene.

In a study of 730 Taiwanese patients with lung cancer and matched controls, never-smoking females having at least one rs763317(A) allele were at increased risk (p = 0.009) for adenocarcinomas; the adjusted odds ratio for the (A;G) genotype was 1.23, CI: 0.87-1.75, and for the (A;A) genotype, the odds ratio was 3.52, CI: 1.32-9.37.[PMID 19026460]


[PMID 20068085OA-icon.png] Analysis of Genetic Variants in Never-Smokers with Lung Cancer Facilitated by an Internet-Based Blood Collection Protocol: A Preliminary Report


[PMID 19190167OA-icon.png] A two-stage case-control study of EGFR polymorphisms and breast cancer risk.