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rs7651446

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(G;G) 0 common/normal
(G;T) 2 1.5x increased risk for epithelial ovarian cancer
(T;T) 2.2 2.25x increased risk for epithelial ovarian cancer
ReferenceGRCh38 38.1/141
Chromosome3
Position156689208
GeneTIPARP
is asnp
is mentioned by
dbSNPrs7651446
ebirs7651446
HLIrs7651446
Exacrs7651446
Varsomers7651446
Maprs7651446
PheGenIrs7651446
hapmaprs7651446
1000 genomesrs7651446
hgdprs7651446
ensemblrs7651446
gopubmedrs7651446
geneviewrs7651446
scholarrs7651446
googlers7651446
pharmgkbrs7651446
gwascentralrs7651446
openSNPrs7651446
23andMers7651446
23andMe allrs7651446
SNP Nexus

SNPshotrs7651446
SNPdbers7651446
MSV3drs7651446
GWAS Ctlgrs7651446
GMAF0.06061
Max Magnitude2.2

rs7651446 is a SNP within the TCDD-inducible poly(ADP-ribose) polymerase TIPARP gene on chromosome 3.

Although not the first report, the first large validation associating the rs7651446(T) allele with increased risk for epithelial ovarian cancer came from a study of 18,174 individuals from 43 studies from the Ovarian Cancer Association Consortium.[PMID 23535730OA-icon.png] Subsequently, another study of over 18,000 patients, including BRCA1 and BRCA2 carriers as well as a meta-analysis, validated this association as the strongest (in terms of increasing risk) of a total of 18 known risk loci. The rs7651466(T) allele was reported as having a hazard ratio of between 1.50 - 1.94, depending on genetic background, with p values 10e-8 or lower.[PMID 25581431OA-icon.png]

? (G;G) (G;T) (T;T) 28
GWAS snp
PMID [PMID 23535730OA-icon.png]
Trait Ovarian cancer
Title GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer.
Risk Allele
P-val 2E-29
Odds Ratio 1.44 [1.35-1.54]