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rs7657958

From SNPedia

Orientationplus
Stabilizedplus
Make rs7657958(A;A)
Make rs7657958(A;G)
Make rs7657958(G;G)
ReferenceGRCh38 38.1/141
Chromosome4
Position68817077
GeneUGT2B10
is asnp
is mentioned by
dbSNPrs7657958
ebirs7657958
HLIrs7657958
Exacrs7657958
Varsomers7657958
Maprs7657958
PheGenIrs7657958
hapmaprs7657958
1000 genomesrs7657958
hgdprs7657958
ensemblrs7657958
gopubmedrs7657958
geneviewrs7657958
scholarrs7657958
googlers7657958
pharmgkbrs7657958
gwascentralrs7657958
openSNPrs7657958
23andMers7657958
23andMe allrs7657958
SNP Nexus

SNPshotrs7657958
SNPdbers7657958
MSV3drs7657958
GWAS Ctlgrs7657958
GMAF0.05556
Max Magnitude
? (A;A) (A;G) (G;G) 28
rs7657958 (Asp67Tyr, 199G>T) is a SNP within the UGT2B10 (UDP-glucuronosyltransferase 2B10) gene.

[PMID 18300939] Tyr allele defines haplotype C, significantly associated with lower 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL, a nitrosamine found in tobacco) N-glucuronidation, an 1.8-fold and 12-fold reduction in NNAL-N-glucuronidation was found for one and two haplotype C alleles, respectively

[PMID 19786624OA-icon.png] may effect nicotine metabolism



GET Evidence
rs7657958
aa_change
aa_change_short
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.0634921
summary