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rs7759938

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) age at menarche ~2 months later on average
(C;T) age at menarche ~1 month later on average
(T;T) normal
ReferenceGRCh38 38.1/141
Chromosome6
Position104931079
is asnp
is mentioned by
dbSNPrs7759938
ebirs7759938
HLIrs7759938
Exacrs7759938
Varsomers7759938
Maprs7759938
PheGenIrs7759938
hapmaprs7759938
1000 genomesrs7759938
hgdprs7759938
ensemblrs7759938
gopubmedrs7759938
geneviewrs7759938
scholarrs7759938
googlers7759938
pharmgkbrs7759938
gwascentralrs7759938
openSNPrs7759938
23andMers7759938
23andMe allrs7759938
SNP Nexus

SNPshotrs7759938
SNPdbers7759938
MSV3drs7759938
GWAS Ctlgrs7759938
GMAF0.3893
Max Magnitude
? (C;C) (C;T) (T;T) 28
rs7759938 is a SNP from chromosomal region 6q21 showing a strong association with age at menarche in a study of 17,500 Icelandic women.

Per copy carried of the rs7759938(T) allele, age at menarche is delayed about 1 month.

GWAS snp
PMID [PMID 19448620OA-icon.png]
Trait Menarche
Title Meta-analysis of genome-wide association data identifies two loci influencing age at menarche
Risk Allele C
P-val 7E-9
Odds Ratio 0.09 [0.05-0.13] years older
GWAS snp
PMID [PMID 21102462OA-icon.png]
Trait
Title Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies
Risk Allele C
P-val 5E-60
Odds Ratio 6.4000 [5.62-7.18] week increase
OMIM606255
Desc
Variant
Relatedalso
OMIM612882
Desc
Variant
Relatedalso


[PMID 22822098] Functional Study of Risk Loci of Stem Cell-associated Gene Lin-28B and Associations with Disease Survival Outcomes in Epithelial Ovarian Cancer

[PMID 20398887OA-icon.png] Distinct variants at LIN28B influence growth in height from birth to adulthood.


GET Evidence
rs7759938
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.632812
summary



[PMID 23152804OA-icon.png] Association of LIN28B with Adult Adiposity-Related Traits in Females

GWAS snp
PMID [PMID 20881960OA-icon.png]
Trait Height
Title Hundreds of variants clustered in genomic loci and biological pathways affect human height.
Risk Allele T
P-val 8E-31
Odds Ratio .05 [NR] unit decrease
GWAS snp
PMID [PMID 23449627OA-icon.png]
Trait Pubertal anthropometrics
Title Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity.
Risk Allele C
P-val 4E-9
Odds Ratio .11 [0.079-0.141] unit increase


[PMID 23740805OA-icon.png] Replication of LIN28B SNP association with age of menarche in young Filipino women