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rs7771980

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) 1 lower bone mineral density in postmenopausal Korean women
(C;T) 1 higher bone mineral density in postmenopausal Spanish women
(T;T) 0 normal
ReferenceGRCh38 38.1/141
Chromosome6
Position45421552
GeneRUNX2
is asnp
is mentioned by
dbSNPrs7771980
ebirs7771980
HLIrs7771980
Exacrs7771980
Varsomers7771980
Maprs7771980
PheGenIrs7771980
hapmaprs7771980
1000 genomesrs7771980
hgdprs7771980
ensemblrs7771980
gopubmedrs7771980
geneviewrs7771980
scholarrs7771980
googlers7771980
pharmgkbrs7771980
gwascentralrs7771980
openSNPrs7771980
23andMers7771980
23andMe allrs7771980
SNP Nexus

SNPshotrs7771980
SNPdbers7771980
MSV3drs7771980
GWAS Ctlgrs7771980
GMAF0.07208
Max Magnitude1
? (C;C) (C;T) (T;T) 28
rs7771980, also known as -1025T>C, is a SNP in the RUNX2 gene, which encodes an osteoblast-specific transcription factor involved in osteoblast differentiation and ossification.

This SNP has been reported to be significantly associated with bone mineral density (BMD; and thus osteoporosis in several studies, but with different correlations.

In a study of 821 Spanish postmenopausal women, rs7771980(C;T) women had higher mean adjusted femoral neck bone BMD values than those bearing the (T;T) genotype.[PMID 17878995]

In a study of 729 postmenopausal Korean women, the significant association found was that (C;C) women showed a significant association with reduced lumbar spine BMD and proximal femur sites compared with (C;T) or (T;T) subjects.[PMID 19424741]


[PMID 18357615OA-icon.png] Differential parental transmission of markers in RUNX2 among cleft case-parent trios from four populations.