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rs7775228

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(T;T) 0
Make rs7775228(C;C)
Make rs7775228(C;T)
ReferenceGRCh38 38.1/141
Chromosome6
Position32690302
GeneHLA-DQB1
is asnp
is mentioned by
dbSNPrs7775228
ebirs7775228
HLIrs7775228
Exacrs7775228
Varsomers7775228
Maprs7775228
PheGenIrs7775228
hapmaprs7775228
1000 genomesrs7775228
hgdprs7775228
ensemblrs7775228
gopubmedrs7775228
geneviewrs7775228
scholarrs7775228
googlers7775228
pharmgkbrs7775228
gwascentralrs7775228
openSNPrs7775228
23andMers7775228
23andMe allrs7775228
SNP Nexus

SNPshotrs7775228
SNPdbers7775228
MSV3drs7775228
GWAS Ctlgrs7775228
GMAF0.1974
Max Magnitude0
? (C;C) (C;T) (T;T) 28
rs7775228 is one of three HLA region SNPs used to tag the DQ2.2 haplotype in gs221. [PMID 18509540OA-icon.png]

rs7775228(T) was found to be associated with increased risk for osteoarthritis among Japanese, but not Europeans, with an odds ratio of 1.34 (CI: 1.21-1.49, combined p = 2.43×10e?8). This SNP is also in linkage disequilibrium with rs10947262, which was found to be associated in multiple populations with osteoarthritis.[PMID 20305777OA-icon.png]

23andMe reports that the C allele at rs7775228 is associated with hay fever (allergic rhinitis and allergy to grass pollen. [PMID 22036096]


[PMID 19950296] Contribution of a haplotype in the HLA region to anti-cyclic citrullinated peptide antibody positivity in rheumatoid arthritis, independently of HLA-DRB1

GWAS snp
PMID [PMID 21804548OA-icon.png]
Trait
Title Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population.
Risk Allele A
P-val 5E-15
Odds Ratio 1.1700 [1.12-1.21]

[PMID 19458352OA-icon.png] Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants.