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rs7787082

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 7x more likely to respond to certain antidepressants
(A;G) 7x more likely to respond to certain antidepressants
(G;G) 0 7x less likely to respond to certain antidepressants
ReferenceGRCh38 38.1/141
Chromosome7
Position87527735
GeneABCB1
is asnp
is mentioned by
dbSNPrs7787082
ebirs7787082
HLIrs7787082
Exacrs7787082
Varsomers7787082
Maprs7787082
PheGenIrs7787082
hapmaprs7787082
1000 genomesrs7787082
hgdprs7787082
ensemblrs7787082
gopubmedrs7787082
geneviewrs7787082
scholarrs7787082
googlers7787082
pharmgkbrs7787082
gwascentralrs7787082
openSNPrs7787082
23andMers7787082
23andMe allrs7787082
SNP Nexus

SNPshotrs7787082
SNPdbers7787082
MSV3drs7787082
GWAS Ctlgrs7787082
GMAF0.3678
Max Magnitude0
? (A;A) (A;G) (G;G) 28
rs7787082 is a SNP in the ABCB1 gene (also known as the MDR1 gene), which encodes a protein that transports certain molecules across the blood-brain barrier. SNPs in ABCB1 may thus influence the intracerebral concentrations of certain drugs and thus their efficacy or potential for adverse side effects. rs7787082 is one of 9 SNPs found within a tight linkage block (r2 >= 0.8 ) such that the minor allele at any one of them predicts (with ~80%+ accuracy) that the other SNPs will also be the minor allele. The list of the 9 SNPs is shown below.

When treated for depression with substrates of the protein encoded by ABCB1, carriers of one or two minor alleles at these ABCB1 SNPs have been reported to respond better than non-carriers. The antidepressant drugs that are known to be substrates include citalopram, paroxetine, amitriptyline, and venlafaxine. The relative odds of better response for rs7787082(G) carriers is 7.72 (CI: 2.8-21.3, p=0.000065) based on a study of ~400 primarily Caucasian patients.10.1016/j.neuron.2007.11.017

The 9 SNPs in the linkage block identified are 10.1016/j.neuron.2007.11.017:



GET Evidence
rs7787082
aa_change
aa_change_short
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.351562
summary



[PMID 22722500] Association study of 27 annotated genes for clozapine pharmacogenetics: validation of preexisting studies and identification of a new candidate gene, ABCB1, for treatment response.


[PMID 26988277] Genetic Association of Curative and Adverse Reactions to Tyrosine Kinase Inhibitors in Chinese advanced Non-Small Cell Lung Cancer patients.