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rs7837688

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(G;G) 2.1 1.7x increased risk for prostate cancer
(G;T) 1.7x increased risk for prostate cancer
(T;T) normal risk
ReferenceGRCh38 38.1/141
Chromosome8
Position127527115
is asnp
is mentioned by
dbSNPrs7837688
ebirs7837688
HLIrs7837688
Exacrs7837688
Varsomers7837688
Maprs7837688
PheGenIrs7837688
hapmaprs7837688
1000 genomesrs7837688
hgdprs7837688
ensemblrs7837688
gopubmedrs7837688
geneviewrs7837688
scholarrs7837688
googlers7837688
pharmgkbrs7837688
gwascentralrs7837688
openSNPrs7837688
23andMers7837688
23andMe allrs7837688
SNP Nexus

SNPshotrs7837688
SNPdbers7837688
MSV3drs7837688
GWAS Ctlgrs7837688
GMAF0.1097
Max Magnitude2.1
? (G;G) (G;T) (T;T) 28
rs7837688 is one of 4 tightly linked SNPs in the "locus 1" region of 8q24 chromosomal region, which has been linked in several studies to prostate cancer, initially through rs1447295.[PMID 17925536]

In a study of 1,563 patients of European ancestry, the odds ratio for prostate cancer associated with risk genotypes of locus 1 were reported as 1.70 (CI: 1.39-2.07). Two other regions of chromosome 8q24 were also studied.[PMID 17925536]

GWAS snp
PMID [PMID 20676098]
Trait
Title Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population
Risk Allele
P-val 1E-25
Odds Ratio None None


[PMID 18231127OA-icon.png] 8q24 and prostate cancer: association with advanced disease and meta-analysis.


[PMID 18535017OA-icon.png] Pooled analysis of genetic variation at chromosome 8q24 and colorectal neoplasia risk.


[PMID 18704501OA-icon.png] Comprehensive resequence analysis of a 136 kb region of human chromosome 8q24 associated with prostate and colon cancers.


[PMID 19528667OA-icon.png] Association of chromosome 8q variants with prostate cancer risk in Caucasian and Hispanic men.


[PMID 21390317OA-icon.png] Characterizing associations and SNP-environment interactions for GWAS-identified prostate cancer risk markers--results from BPC3.


[PMID 21455501OA-icon.png] Genetic variants on chromosome 8q24 and colorectal neoplasia risk: a case-control study in China and a meta-analysis of the published literature.


[PMID 22382457OA-icon.png] Racial disparities in the association between variants on 8q24 and prostate cancer: a systematic review and meta-analysis.


[PMID 23532531] Common Variants at 8q24 are Associated with Prostate Cancer Risk in Serbian Population