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rs78943174

From SNPedia

rs78943174 has been associated with prostate cancer aggressiveness.
Orientationplus
Stabilizedplus
Make rs78943174(C;C)
Make rs78943174(C;T)
Make rs78943174(T;T)
Chromosome3
Position175534948
GeneNAALADL2
is asnp
is mentioned by
dbSNPrs78943174
ebirs78943174
HLIrs78943174
Exacrs78943174
Varsomers78943174
Maprs78943174
PheGenIrs78943174
hapmaprs78943174
1000 genomesrs78943174
hgdprs78943174
ensemblrs78943174
gopubmedrs78943174
geneviewrs78943174
scholarrs78943174
googlers78943174
pharmgkbrs78943174
gwascentralrs78943174
openSNPrs78943174
23andMers78943174
23andMe allrs78943174
SNP Nexus

SNPshotrs78943174
SNPdbers78943174
MSV3drs78943174
GWAS Ctlgrs78943174
Max Magnitude

rs78943174 is a single-nucleotide polymorphism (SNP) found in the gene NAALADL2 that has been associated with prostate cancer aggressiveness as measured by the Gleason score.

Prostate cancer is a type of cancer that forms in tissues of the prostate. It usually shows a slow growth and remains confined to the prostate gland not causing serious harm, but other types of prostate cancer can spread quickly and are aggressive. Aggressiveness can be measured with the Gleason score, a system which assigns a number from 2 to 10 to describe how abnormal the cells appear under a microscope. The higher the Gleason score is, the more aggressive the disease is.

To evaluate disease aggressiveness, a multi-stage, case-only GWAS was conducted with a total of 12,518 prostate cancer cases of European ancestry. Regression models were fit taking the Gleason score as a quantitative trait and adjusting for age [PMID 25939597OA-icon.png]. rs78943174 (3q26.31) reached genome-wide significance (p = 4.18x10-8), with the C allele associated with higher Gleason score (more aggressive disease). The estimated coefficient for this SNP in the regression model is 0.289 with standard error of 0.053. The risk allele (C) frequency among cases is 0.985. The non-risk at rs78943174 is T.

rs78943174 is intronic to the N-acetylated alpha-linked acidic dipeptidase-like2 (NAALADL2) gene, which is related to prostate-specific membrane antigen, a well characterized diagnostic indicator and potential drug target of prostate cancer. Variants in NAALADL2 have also been identified to be associated with Kawasaki disease.

[PMID 25939597OA-icon.png] Two susceptibility loci identified for prostate cancer aggressiveness.