Have questions? Visit https://www.reddit.com/r/SNPedia

rs7901695

From SNPedia

Orientationplus
Stabilizedplus
Make rs7901695(C;C)
Make rs7901695(C;T)
Make rs7901695(T;T)
ReferenceGRCh38 38.1/142
Chromosome10
Position112994329
GeneTCF7L2
is asnp
is mentioned by
dbSNPrs7901695
ebirs7901695
HLIrs7901695
Exacrs7901695
Varsomers7901695
Maprs7901695
PheGenIrs7901695
hapmaprs7901695
1000 genomesrs7901695
hgdprs7901695
ensemblrs7901695
gopubmedrs7901695
geneviewrs7901695
scholarrs7901695
googlers7901695
pharmgkbrs7901695
gwascentralrs7901695
openSNPrs7901695
23andMers7901695
23andMe allrs7901695
SNP Nexus

SNPshotrs7901695
SNPdbers7901695
MSV3drs7901695
GWAS Ctlgrs7901695
GMAF0.2658
Max Magnitude
? (C;C) (C;T) (T;T) 28
[PMID 17668382OA-icon.png] implicated in type-2 diabetes according to this Gene Sherpas post

Extensive blog post theorizing this snp may activate a cryptic exon.


[PMID 19056611OA-icon.png] Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data

GWAS snp
PMID [PMID 17463249OA-icon.png]
Trait Type 2 diabetes
Title Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes
Risk Allele C
P-val 9.9999999999999997E-49
Odds Ratio 1.37 [1.31-1.43]
OMIM602228
DescTRANSCRIPTION FACTOR 7-LIKE 2; TCF7L2
Variant
Relatedalso
GWAS snp
PMID [PMID 21347282OA-icon.png]
Trait
Title Genome-Wide Association Study of Coronary Heart Disease and Its Risk Factors in 8,090 African Americans: The NHLBI CARe Project
Risk Allele
P-val 0.000001
Odds Ratio 1.1900 [1.11-1.28]


[PMID 22402060OA-icon.png] Functional analysis of TCF7L2 genetic variants associated with type 2 diabetes


[PMID 22441719] Stronger Association of Common Variants in TCF7L2 Gene with Nonobese Type 2 Diabetes in the Latvian Population


[PMID 22584884] The Effect of Type 2 Diabetes Risk Loci on Insulin Requirements in Type 1 Diabetes


[PMID 15047616] A role for the malonyl-CoA/long-chain acyl-CoA pathway of lipid signaling in the regulation of insulin secretion in response to both fuel and nonfuel stimuli

[PMID 16936218] Polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in the Amish: replication and evidence for a role in both insulin secretion and insulin resistance.

[PMID 17245407] TCF7L2 polymorphisms are associated with type 2 diabetes in northern Sweden.

[PMID 17245589] A genetic variation of the transcription factor 7-like 2 gene is associated with risk of type 2 diabetes in the Japanese population.

[PMID 17311858] TCF7L2 gene polymorphisms confer an increased risk for early impairment of glucose metabolism and increased height in obese children.

[PMID 17340123] Replication study for the association of TCF7L2 with susceptibility to type 2 diabetes in a Japanese population.

[PMID 17601994] Variants of the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in an African-American population enriched for nephropathy.

[PMID 17661009OA-icon.png] Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms.

[PMID 17786212OA-icon.png] Heterogeneity in meta-analyses of genome-wide association investigations.

[PMID 17934151] A variant of the transcription factor 7-like 2 (TCF7L2) gene and the risk of posttransplantation diabetes mellitus in renal allograft recipients.

[PMID 17971425OA-icon.png] Association of TCF7L2 gene polymorphisms with reduced acute insulin response in Hispanic Americans.

[PMID 18268068OA-icon.png] Variation in TCF7L2 and increased risk of colon cancer: the Atherosclerosis Risk in Communities (ARIC) Study.

[PMID 18291022OA-icon.png] Common variants of the TCF7L2 gene are associated with increased risk of type 2 diabetes mellitus in a UK-resident South Asian population.

[PMID 18437354OA-icon.png] TCF7L2 single nucleotide polymorphisms, cardiovascular disease and all-cause mortality: the Atherosclerosis Risk in Communities (ARIC) study.

[PMID 18469204OA-icon.png] Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6,719 Asians.

[PMID 18533027OA-icon.png] Worldwide population differentiation at disease-associated SNPs.

[PMID 18591388OA-icon.png] Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk.

[PMID 18650481OA-icon.png] TCF7L2 variants associate with CKD progression and renal function in population-based cohorts.

[PMID 18655717OA-icon.png] Weak or no association of TCF7L2 variants with Type 2 diabetes risk in an Arab population.

[PMID 18712344] Association of variants of the TCF7L2 gene with increases in the risk of type 2 diabetes and the proinsulin:insulin ratio in the Spanish population.

[PMID 18780302OA-icon.png] Association studies of 22 candidate SNPs with late-onset Alzheimer's disease.

[PMID 19050058OA-icon.png] Single nucleotide transcription factor 7-like 2 (TCF7L2) gene polymorphisms in antiislet autoantibody-negative patients at onset of diabetes.

[PMID 19053027] Loci of TCF7L2, HHEX and IDE on chromosome 10q and the susceptibility of their genetic polymorphisms to type 2 diabetes.

[PMID 19096518OA-icon.png] Novel association of HK1 with glycated hemoglobin in a non-diabetic population: a genome-wide evaluation of 14,618 participants in the Women's Genome Health Study.

[PMID 19161620OA-icon.png] An open access database of genome-wide association results.

[PMID 19207020OA-icon.png] Meta-analysis in genome-wide association studies.

[PMID 19228405OA-icon.png] Association between TCF7L2 gene polymorphisms and susceptibility to type 2 diabetes mellitus: a large Human Genome Epidemiology (HuGE) review and meta-analysis.

[PMID 19323962OA-icon.png] Genome-wide association studies in type 2 diabetes.

[PMID 19463184OA-icon.png] Worldwide patterns of haplotype diversity at 9p21.3, a locus associated with type 2 diabetes and coronary heart disease.

[PMID 19526209OA-icon.png] Is the thrifty genotype hypothesis supported by evidence based on confirmed type 2 diabetes- and obesity-susceptibility variants?

[PMID 19602701OA-icon.png] Underlying genetic models of inheritance in established type 2 diabetes associations.

[PMID 19750184OA-icon.png] Genome-wide association studies for atherosclerotic vascular disease and its risk factors.

[PMID 19913122OA-icon.png] ATRIUM: testing untyped SNPs in case-control association studies with related individuals.

[PMID 19924244OA-icon.png] TCF7L2 polymorphism rs7903146 is associated with coronary artery disease severity and mortality.

[PMID 19931040OA-icon.png] Simultaneous genotype calling and haplotype phasing improves genotype accuracy and reduces false-positive associations for genome-wide association studies.

[PMID 20017978OA-icon.png] Influence of control selection in genome-wide association studies: the example of diabetes in the Framingham Heart Study.

[PMID 20075150OA-icon.png] Utility of genetic and non-genetic risk factors in prediction of type 2 diabetes: Whitehall II prospective cohort study.

[PMID 20144327OA-icon.png] A genomics study of type 2 diabetes mellitus in U.S. Air Force personnel.

[PMID 21159844] Variants and haplotypes of TCF7L2 are associated with beta-cell function in patients with newly diagnosed type 2 diabetes: the Verona Newly Diagnosed Type 2 Diabetes Study (VNDS) 1.

[PMID 21278902OA-icon.png] Genetic risk profiling for prediction of type 2 diabetes.

[PMID 21672010OA-icon.png] Gestational diabetes mellitus is associated with TCF7L2 gene polymorphisms independent of HLA-DQB1*0602 genotypes and islet cell autoantibodies.

[PMID 21898192] Worldwide distribution of type II diabetes-associated TCF7L2 SNPs: evidence for stratification in Europe.

[PMID 22377712] Association between type 2 diabetes genetic susceptibility loci and visceral and subcutaneous fat area as determined by computed tomography.


GET Evidence
rs7901695
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.296875
summary



[PMID 23188737] TCF7L2 gene polymorphisms and type 2 diabetes risk: a comprehensive and updated meta-analysis involving 121,174 subjects


[PMID 22480428] T2D risk haplotypes of the TCF7L2 gene in the Czech population sample: the association with free fatty acids composition.


[PMID 22843023] TCF7L2 gene polymorphisms and type 2 diabetes: association with diabetic retinopathy and cardiovascular autonomic neuropathy.


[PMID 23107111] Transcription factor-7-like 2 gene variants are strongly associated with type 2 diabetes in Lebanese subjects.


[PMID 23456907OA-icon.png] Maternal genotype and gestational diabetes.


[PMID 23462794OA-icon.png] Identification of CpG-SNPs associated with type 2 diabetes and differential DNA methylation in human pancreatic islets.