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rs7910977

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) 0 common in complete genomics
(C;T) 1 ~0.80x (lower) risk for late onset Alzheimer's disease
(T;T) 1 ~0.80x (lower) risk for late onset Alzheimer's disease
ReferenceGRCh38 38.1/142
Chromosome10
Position92450119
GeneIDE
is asnp
is mentioned by
dbSNPrs7910977
ebirs7910977
HLIrs7910977
Exacrs7910977
Varsomers7910977
Maprs7910977
PheGenIrs7910977
hapmaprs7910977
1000 genomesrs7910977
hgdprs7910977
ensemblrs7910977
gopubmedrs7910977
geneviewrs7910977
scholarrs7910977
googlers7910977
pharmgkbrs7910977
gwascentralrs7910977
openSNPrs7910977
23andMers7910977
23andMe allrs7910977
SNP Nexus

SNPshotrs7910977
SNPdbers7910977
MSV3drs7910977
GWAS Ctlgrs7910977
GMAF0.18
Max Magnitude1
? (C;C) (C;T) (T;T) 28
rs7910977 is a SNP of the IDE gene, which encodes the insulin-degrading enzyme.

Late onset Alzheimer's disease is a neurodegenerative condition in which the brain develops large numbers of extracellular senile plaques composed primarily of aggregated amyloid-B proteins as well as intraneuronal neurofibrillary tangles composed mainly of aggregated tau protein.[PMID 15450169] One notable function of insulin-degrading enzyme is its ability to degrade amyloid-B and therefore to influence the amount of amyloid-B found in the brain.[PMID 12634421OA-icon.png]

The rs7910977(T) allele is associated with reduced risk of Alzheimer's disease in one study of ~3,000 patients, and in this study, the conclusion was that it was most likely due to near perfect linkage with rs6583817, a nearby functional variant. rs6583817(T) allele carriers had an odds ratio for late onset Alzheimer's disease of around 0.80 (p<0.03).[PMID 20098734OA-icon.png]


[PMID 20142614OA-icon.png] Gene expression levels as endophenotypes in genome-wide association studies of Alzheimer disease

OMIM605526
Desc
Variant
Relatedalso


[PMID 24477584] Genetic association of IDE, POU2F1, PON1, IL1α and IL1β with type 2 diabetes in Pakistani population