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rs795484

From SNPedia

Linked to morphine dose and postoperative pain in tonsillectomy and adenoidectomy
Orientationminus
Stabilizedminus
Geno Mag Summary
(A;A) 2.5 Even more increased morphine dose requirement and postoperative pain in tonsillectomy and adenoidectomy
(A;G) 2.1 Increased morphine dose requirement and postoperative pain in tonsillectomy and adenoidectomy
(G;G) 1.1 Normal morphine dose requirement and postoperative pain in tonsillectomy and adenoidectomy
ReferenceGRCh38 38.1/142
Chromosome12
Position118152057
GeneTAOK3
is asnp
is mentioned by
dbSNPrs795484
ebirs795484
HLIrs795484
Exacrs795484
Varsomers795484
Maprs795484
PheGenIrs795484
hapmaprs795484
1000 genomesrs795484
hgdprs795484
ensemblrs795484
gopubmedrs795484
geneviewrs795484
scholarrs795484
googlers795484
pharmgkbrs795484
gwascentralrs795484
openSNPrs795484
23andMers795484
23andMe allrs795484
SNP Nexus

SNPshotrs795484
SNPdbers795484
MSV3drs795484
GWAS Ctlgrs795484
Max Magnitude2.5
? (A;A) (A;G) (G;G) 28
GWAS snp
PMID [PMID 24909733OA-icon.png]
Trait Morphine dose requirement in tonsillectomy and adenoidectomy surgery
Title TAOK3, a novel genome-wide association study locus associated with morphine requirement and postoperative pain in a retrospective pediatric day surgery population.
Risk Allele A
P-val 3E-7
Odds Ratio 16.10 [10.0-21.1] unit increase

Each minor allele at rs795484 (guanine [G]>adenine [A]) contributed +17.6 μg/kg (95% confidence interval [CI] 10.7-24.4) to dose. Effect direction and magnitude were replicated in an independent cohort of 75 EC children (P<0.05). No association with morphine dose was detected in African Americans (AA) (n=241). Postoperative pain scores ≥ 7/10 were associated with rs795484 (G>A) in the EC cohort (odds ratio 2.35, 95% CI 1.56-3.52, P<0.00005) and this association replicated in AA children (odds ratio 1.76, 95% CI 1.14-2.71, P<0.01).

[PMID 24909733]