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rs7977109

From SNPedia

Orientationplus
Stabilizedplus
Make rs7977109(A;A)
Make rs7977109(A;G)
Make rs7977109(G;G)
ReferenceGRCh38 38.1/141
Chromosome12
Position117292535
GeneNOS1
is asnp
is mentioned by
dbSNPrs7977109
ebirs7977109
HLIrs7977109
Exacrs7977109
Varsomers7977109
Maprs7977109
PheGenIrs7977109
hapmaprs7977109
1000 genomesrs7977109
hgdprs7977109
ensemblrs7977109
gopubmedrs7977109
geneviewrs7977109
scholarrs7977109
googlers7977109
pharmgkbrs7977109
gwascentralrs7977109
openSNPrs7977109
23andMers7977109
23andMe allrs7977109
SNP Nexus

SNPshotrs7977109
SNPdbers7977109
MSV3drs7977109
GWAS Ctlgrs7977109
GMAF0.3641
Max Magnitude
? (A;A) (A;G) (G;G) 28

After scanning a region of chromosome 12 previously linked to restless legs syndrome in ~900 patients, German investigators found SNPs within the NOS1 gene to be most associated with the syndrome. SNP rs7977109 yielded an odds ratio of 0.76 (CI: 0.64 -0.90, p=-.002). The risk allele is said to be defined in Supplementary materials available online, but they aren't. Furthermore, the significant association seen for this SNP and one other (rs693534) are in opposite directions in the explorative versus the replication populations.[PMID 18058820]

[PMID 20401335OA-icon.png] Sickle Cell Disease in the Post Genomic Era: A Monogenic Disease with a Polygenic Phenotype.