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rs79874540

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(C;C) 0 common in complete genomics
(C;T) 3.3 2-3 fold higher risk of impulsive/aggressive behaviour when drunk
(T;T) 3.3 Increased risk for impulsive/aggressive behaviour when drunk
ReferenceGRCh38 38.1/141
Chromosome2
Position231123707
GeneHTR2B, PSMD1
is asnp
is mentioned by
dbSNPrs79874540
ebirs79874540
HLIrs79874540
Exacrs79874540
Varsomers79874540
Maprs79874540
PheGenIrs79874540
hapmaprs79874540
1000 genomesrs79874540
hgdprs79874540
ensemblrs79874540
gopubmedrs79874540
geneviewrs79874540
scholarrs79874540
googlers79874540
pharmgkbrs79874540
gwascentralrs79874540
openSNPrs79874540
23andMers79874540
23andMe allrs79874540
SNP Nexus

SNPshotrs79874540
SNPdbers79874540
MSV3drs79874540
GWAS Ctlgrs79874540
GMAF0.0009183
Max Magnitude3.3

rs79874540, known in the literature primarily as Q20* or Q20X, represents an uncommon variant in the HTR2B gene on chromosome 2 found almost exclusively in those of Finnish origin.

A 2010 paper concluded that the rs79874540(T) variant, carried by 2.2% of the population in Finland, was associated with somewhat (2 - 3 fold?) increased risk for impulsive and/or aggressive behaviour, especially when under the influence of alcohol. The number of men studied was not particularly high.[PMID 21179162OA-icon.png]

A 2015 follow-up study using a personality questionnaire by the same researchers of 14 heterozygous HTR2B Q20* carriers and 156 healthy controls lacking HTR2B Q20* reinforced the "aggressive when drunk" association for the Q20* allele carriers, but also noted that the Q20* carriers were neither alcoholics per se (as measured by average alcohol consumption) nor diagnosed as alcoholics, even if they had a tendency to lose behavioral control while under the influence of alcohol.[PMID 26575222]

In 2016, other Finnish researchers observed that at least for Finnish males having an antisocial personality disorder, Q20* carriers who also had low or normal testosterone levels were at lower risk for obesity than non-carriers.[PMID 27420381]