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rs8007267

From SNPedia

Orientationplus
Stabilizedplus
Make rs8007267(C;C)
Make rs8007267(C;T)
Make rs8007267(T;T)
ReferenceGRCh38 38.1/141
Chromosome14
Position54912273
GeneGCH1
is asnp
is mentioned by
dbSNPrs8007267
ebirs8007267
HLIrs8007267
Exacrs8007267
Varsomers8007267
Maprs8007267
PheGenIrs8007267
hapmaprs8007267
1000 genomesrs8007267
hgdprs8007267
ensemblrs8007267
gopubmedrs8007267
geneviewrs8007267
scholarrs8007267
googlers8007267
pharmgkbrs8007267
gwascentralrs8007267
openSNPrs8007267
23andMers8007267
23andMe allrs8007267
SNP Nexus

SNPshotrs8007267
SNPdbers8007267
MSV3drs8007267
GWAS Ctlgrs8007267
GMAF0.2874
Max Magnitude
? (C;C) (C;T) (T;T) 28
GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence. T allele associated with higher tolerance to pain.[PMID 17057711]

Do genetic predictors of pain sensitivity associate with persistent widespread pain? T allele associated with higher pain tolerance.[PMID 19775452OA-icon.png]

GCH1 haplotype determines vascular and plasma biopterin availability in coronary artery disease effects on vascular superoxide production and endothelial function. Part of a haplotype, rs10483639(C)-rs3783641(A)-rs8007267(T), associated with lower levels of tetrahydrobiopterin.[PMID 18598896OA-icon.png]


[PMID 17343757OA-icon.png] Lack of influence of GTP cyclohydrolase gene (GCH1) variations on pain sensitivity in humans.


[PMID 17363416] Reliable screening for a pain-protective haplotype in the GTP cyclohydrolase 1 gene (GCH1) through the use of 3 or fewer single nucleotide polymorphisms.


[PMID 19014702OA-icon.png] Does the pain-protective GTP cyclohydrolase haplotype significantly alter the pattern or severity of pain in humans with chronic pancreatitis?


[PMID 19081190OA-icon.png] Polymorphisms in the GTP cyclohydrolase gene (GCH1) are associated with ratings of capsaicin pain.


[PMID 19751821OA-icon.png] Oxidative risk for atherothrombotic cardiovascular disease.


[PMID 20633294OA-icon.png] Different SNP combinations in the GCH1 gene and use of labor analgesia.


[PMID 20842020] Catecholamine-o-methyltransferase polymorphisms are associated with postoperative pain intensity.


[PMID 23059057OA-icon.png] A GCH1 haplotype and risk of neural tube defects in the National Birth Defects Prevention Study


[PMID 22770721] GTP cyclohydrolase 1 gene haplotypes as predictors of SSRI response in Japanese patients with major depressive disorder