rs80359877

minus

Geno	Mag	Summary
(-;TGTCCCATCTG)	6	BRCA1 variant considered pathogenic for breast cancer
(TGTCCCATCTG;TGTCCCATCTG)	0	common in clinvar

Make rs80359877(-;-)

Reference

GRCh38 38.1/141

Chromosome

17

Position

43124017

Gene	BRCA1, NBR2

is a	snp
is	mentioned by
dbSNP	rs80359877
dbSNP (classic)	rs80359877
ClinGen	rs80359877
ebi	rs80359877
HLI	rs80359877
Exac	rs80359877
Gnomad	rs80359877
Varsome	rs80359877
LitVar	rs80359877
Map	rs80359877
PheGenI	rs80359877
Biobank	rs80359877
1000 genomes	rs80359877
hgdp	rs80359877
ensembl	rs80359877
geneview	rs80359877
scholar	rs80359877
google	rs80359877
pharmgkb	rs80359877
gwascentral	rs80359877
openSNP	rs80359877
23andMe	rs80359877
SNPshot	rs80359877
SNPdbe	rs80359877
MSV3d	rs80359877
GWAS Ctlg	rs80359877

Status

Merged into rs80357696

Max Magnitude

6

rs80359877, also known as 189del11, c.70_80del and p.Cys24_Cys27?fs, is a variant in the BRCA1 gene considered pathogenic for breast cancer in ClinVar.

ClinVar
Risk
Alt
Reference	Rs80359877(TGTCCCATCTG;TGTCCCATCTG)
Significance	Pathogenic
Disease	Hereditary breast and ovarian cancer syndrome Breast-ovarian cancer Hereditary cancer-predisposing syndrome
Variation	info
Gene	NBR2 BRCA1
CLNDBN	Hereditary breast and ovarian cancer syndrome Breast-ovarian cancer, familial 1 Hereditary cancer-predisposing syndrome
Reversed	1
HGVS	NC_000017.10:g.41276034_41276044delCAGATGGGACA
CLNSRC	Breast Cancer Information Core (BRCA1)
CLNACC	RCV000049106.3, RCV000111682.3, RCV000131391.3,