|(A;A)||1.4||1.4x increased risk for T2D in some populations|
|(A;C)||1.2||1.2x increased risk for T2D in some populations|
This SNP did not show any association with obesity, type-2 diabetes or any other related traits in a study of 3,210 Chinese subjects. Furthermore, the minor allele frequency was much lower in Chinese populations compared to populations of European descent.[PMID 17959933]
However, a more recent study of 4,189 Chinese Han subjects combined with a meta-analysis of published studies concluded that rs8050136(A) was associated with both increased risk for type-2 diabetes and obesity.[PMID 20057365]
[PMID 19053021] rs8050136 associated with increased food intake, but not of impaired energy expenditure.
|Condition||Type 2 diabetes|
[PMID 19303973] RARRES2, encoding the novel adipokine chemerin, is a genetic determinant of disproportionate regional body fat distribution: a comparative magnetic resonance imaging study.
[PMID 19056611] Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data
|Trait||Body mass index|
|Title||Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity|
|Odds Ratio||8.04 [6.96-9.12] % SD|
|Trait||Type 2 diabetes|
|Title||Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes|
|Odds Ratio||1.15 [1.09-1.22]|
[PMID 19322589] Analysis of FTO gene variants with measures of obesity and glucose homeostasis in the IRAS Family Study
[PMID 19543202] FTO Genotype Is Associated With Exercise Training-induced Changes in Body Composition
|Trait||Type 2 diabetes|
|Title||A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants|
|Odds Ratio||1.17 [1.12-1.22]|
[PMID 19584900] Association of FTO variants with BMI and fat mass in the self-contained population of Sorbs in Germany[PMID 19798072] FTO Genotype and the Weight Loss Benefits of Moderate Intensity Exercise
[PMID 20061430] Obesity Susceptibility Genetic Variants Identified from Recent Genome-Wide Association Studies: Implications in a Chinese Population
[PMID 19833889] Genetic heterogeneity in latent autoimmune diabetes is linked to various degrees of autoimmune activity: results from the Nord-Trøndelag Health Study
[PMID 20337217] FTO polymorphisms are associated with obesity but not with diabetes in East Asian populations: a meta-analysis
[PMID 20647405] No Association between FTO or HHEX and Endometrial Cancer Risk
[PMID 21037323] Cut-like homeobox 1 (CUX1) regulates expression of the fat mass and obesity-associated (FTO) and retinitis pigmentosa gtpase regulator interacting protein-1 like (RPGRIPIL) genes, and co-ordinates leptin receptor signaling
[PMID 21124985] Integrated Genetic and Epigenetic Analysis Identifies Haplotype-Specific Methylation in the FTO Type 2 Diabetes and Obesity Susceptibility Locus
[PMID 21266646] Lifestyle Interaction With Fat Mass and Obesity-Associated (FTO) Genotype and Risk of Obesity in Apparently Healthy U.S. Women
|Title||Genome-Wide Association Analysis of Body Mass in Chronic Obstructive Pulmonary Disease|
|Odds Ratio||None None|
|Title||Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile.|
|Odds Ratio||0.0600 [NR] % decrease|
[PMID 21796137] Association of variations in the FTO, SCG3 and MTMR9 genes with metabolic syndrome in a Japanese population
[PMID 21868005] Variations in the fat mass and obesity-associated (FTO) gene are related to glucose levels and higher lipid accumulation product in postmenopausal women from southern Brazil
[PMID 22051089] Associations of Obesity Genes with Obesity-related Outcomes in Multiethnic Children
[PMID 22355368] Longitudinal Replication Studies of GWAS Risk SNPs Influencing Body Mass Index over the Course of Childhood and Adulthood
[PMID 17786212] Heterogeneity in meta-analyses of genome-wide association investigations.
[PMID 17928989] Variations in the HHEX gene are associated with increased risk of type 2 diabetes in the Japanese population.
[PMID 18162508] Association of CDKAL1, IGF2BP2, CDKN2A/B, HHEX, SLC30A8, and KCNJ11 with susceptibility to type 2 diabetes in a Japanese population.
[PMID 18224312] Pharmacogenetics: data, concepts and tools to improve drug discovery and drug treatment.
[PMID 18251005] Inverse relationship between obesity and FTO gene expression in visceral adipose tissue in humans.
[PMID 18256137] Regulation of Fto/Ftm gene expression in mice and humans.
[PMID 18335027] Association analysis of the FTO gene with obesity in children of Caucasian and African ancestry reveals a common tagging SNP.
[PMID 18379722] Variations in the FTO gene are associated with severe obesity in the Japanese.
[PMID 18423522] Estimating odds ratios in genome scans: an approximate conditional likelihood approach.
[PMID 18426861] Association analysis of type 2 diabetes Loci in type 1 diabetes.
[PMID 18443202] Association analysis in african americans of European-derived type 2 diabetes single nucleotide polymorphisms from whole-genome association studies.
[PMID 18445669] Lack of association of fatness-related FTO gene variants with energy expenditure or physical activity.
[PMID 18469204] Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6,719 Asians.
[PMID 18487448] Common variation in the fat mass and obesity-associated (FTO) gene confers risk of obesity and modulates BMI in the Chinese population.
[PMID 18535549] Impact of variation in the FTO gene on whole body fat distribution, ectopic fat, and weight loss.
[PMID 18591388] Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk.
[PMID 18599522] FTO variants are associated with obesity in the Chinese and Malay populations in Singapore.
[PMID 18689899] Exchangeable models of complex inherited diseases.
[PMID 18694974] Predicting type 2 diabetes based on polymorphisms from genome-wide association studies: a population-based study.
[PMID 18782870] Clinical review: the genetics of type 2 diabetes: a realistic appraisal in 2008.
[PMID 18787525] FTO polymorphisms are associated with obesity but not diabetes risk in postmenopausal women.
[PMID 18852197] Metabolic and cardiovascular traits: an abundance of recently identified common genetic variants.
[PMID 18991055] Association between polymorphisms in SLC30A8, HHEX, CDKN2A/B, IGF2BP2, FTO, WFS1, CDKAL1, KCNQ1 and type 2 diabetes in the Korean population.
[PMID 19002430] Type 2 diabetes-associated genetic variants discovered in the recent genome-wide association studies are related to gestational diabetes mellitus in the Korean population.
[PMID 19008344] Association analysis of variation in/near FTO, CDKAL1, SLC30A8, HHEX, EXT2, IGF2BP2, LOC387761, and CDKN2B with type 2 diabetes and related quantitative traits in Pima Indians.
[PMID 19074959] ATOM: a powerful gene-based association test by combining optimally weighted markers.
[PMID 19096518] Novel association of HK1 with glycated hemoglobin in a non-diabetic population: a genome-wide evaluation of 14,618 participants in the Women's Genome Health Study.
[PMID 19161620] An open access database of genome-wide association results.
[PMID 19207020] Meta-analysis in genome-wide association studies.
[PMID 19323962] Genome-wide association studies in type 2 diabetes.
[PMID 19341491] Genome-based prediction of common diseases: methodological considerations for future research.
[PMID 19401414] Confirmation of multiple risk Loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population.
[PMID 19460916] Genetic architecture of type 2 diabetes: recent progress and clinical implications.
[PMID 19474294] Potential etiologic and functional implications of genome-wide association loci for human diseases and traits.
[PMID 19478790] The role of obesity-associated loci identified in genome-wide association studies in the determination of pediatric BMI.
[PMID 19553259] Common body mass index-associated variants confer risk of extreme obesity.
[PMID 19602701] Underlying genetic models of inheritance in established type 2 diabetes associations.
[PMID 19741467] Association of common type 2 diabetes risk gene variants and posttransplantation diabetes mellitus in renal allograft recipients in Korea.
[PMID 19862325] PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese population.
[PMID 19931040] Simultaneous genotype calling and haplotype phasing improves genotype accuracy and reduces false-positive associations for genome-wide association studies.
[PMID 20009087] Genetic variation at the FTO locus influences RBL2 gene expression.
[PMID 20017965] Identifying association under a previous linkage peak on chromosome 16 for body mass index using cross-sectional and longitudinal data of the Framingham Heart Study.
[PMID 20017978] Influence of control selection in genome-wide association studies: the example of diabetes in the Framingham Heart Study.
[PMID 20018066] Epistatic interactions of CDKN2B-TCF7L2 for risk of type 2 diabetes and of CDKN2B-JAZF1 for triglyceride/high-density lipoprotein ratio longitudinal change: evidence from the Framingham Heart Study.
[PMID 20049090] Association between type 2 diabetes loci and measures of fatness.
[PMID 20080751] Long-range gene regulation links genomic type 2 diabetes and obesity risk regions to HHEX, SOX4, and IRX3.
[PMID 20126254] Rare variants create synthetic genome-wide associations.
[PMID 20127379] From monogenic to polygenic obesity: recent advances.
[PMID 20144327] A genomics study of type 2 diabetes mellitus in U.S. Air Force personnel.
[PMID 20161779] Investigation of type 2 diabetes risk alleles support CDKN2A/B, CDKAL1, and TCF7L2 as susceptibility genes in a Han Chinese cohort.
[PMID 20377915] FTO variant rs9939609 is associated with body mass index and waist circumference, but not with energy intake or physical activity in European- and African-American youth.
[PMID 20381893] The genetics of obesity: FTO leads the way.
[PMID 20421936] Two new Loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and german study groups.
[PMID 20442772] Common SNPs in FTO gene are associated with obesity related anthropometric traits in an island population from the eastern Adriatic coast of Croatia.
[PMID 20502638] Risk of type 2 diabetes and obesity is differentially associated with variation in FTO in whites and African-Americans in the ARIC study.
[PMID 20509872] Implication of genetic variants near SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, FTO, TCF2, KCNQ1, and WFS1 in type 2 diabetes in a Chinese population.
[PMID 20532014] The epidemiology of diabetes in Korea: from the economics to genetics.
[PMID 20694148] A genome-wide association study of the metabolic syndrome in Indian Asian men.
[PMID 20712903] Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study.
[PMID 21102551] Analysis of FTO gene variants with obesity and glucose homeostasis measures in the multiethnic Insulin Resistance Atherosclerosis Study cohort.
[PMID 21147891] Genetic variants associated with persistent central obesity and the metabolic syndrome in a 12-year longitudinal study.
[PMID 21175269] Genetic variations in the FTO gene are associated with type 2 diabetes and obesity in south Indians (CURES-79).
[PMID 21278902] Genetic risk profiling for prediction of type 2 diabetes.
[PMID 21283728] Genetic variants of diabetes risk and incident cardiovascular events in chronic coronary artery disease.
[PMID 21283731] FTO and MC4R gene variants are associated with obesity in polycystic ovary syndrome.
[PMID 21317302] FTO polymorphisms are associated with adult body mass index (BMI) and colorectal adenomas in African-Americans.
[PMID 21445555] Association study of type 2 diabetes genetic susceptibility variants and risk of pancreatic cancer: an analysis of PanScan-I data.
[PMID 22189543] Genetic variants in FTO associated with metabolic syndrome: a meta- and gene-based analysis.
[PMID 22377712] Association between type 2 diabetes genetic susceptibility loci and visceral and subcutaneous fat area as determined by computed tomography.
|qualified_impact||Insufficiently evaluated pathogenic|
[PMID 23091647] Common Variants of FTO Are Associated with Childhood Obesity in a Cross-Sectional Study of 3,126 Urban Indian Children
[PMID 23284729] Aerobic Fitness Does Not Modify the Effect of FTO Variation on Body Composition Traits
[PMID 23512716] Association between obesity-related gene FTO and ADHD
|Trait||Type 2 diabetes|
|Title||Genome-wide association study for type 2 diabetes in indians identifies a new susceptibility locus at 2q21.|
|Odds Ratio||1.16 [1.09-1.24]|
[PMID 22901973] Fat mass and obesity-associated gene polymorphisms do not affect metabolic response to hormone therapy in healthy postmenopausal women
[PMID 23820787] Association of the FTO Obesity Risk Variant rs8050136 With Percentage of Energy Intake From Fat in Multiple Racial/Ethnic Populations: The PAGE Study
[PMID 23990951] Association of genetic variants with isolated fasting hyperglycaemia and isolated postprandial hyperglycaemia in a han chinese population
[PMID 24348519] EMR-linked GWAS study: investigation of variation landscape of loci for body mass index in children
[PMID 22847851] Insulin resistant phenotype of polycystic ovary syndrome does not seem to be caused by variation in FTO.
[PMID 22956599] Evaluation of the genetic overlap between osteoarthritis with body mass index and height using genome-wide association scan data.
[PMID 23298195] Association study of genetic variants of 17 diabetes-related genes/loci and cardiovascular risk and diabetic nephropathy in the Chinese She population.
[PMID 23300277] The influence of obesity-related single nucleotide polymorphisms on BMI across the life course: the PAGE study.
[PMID 23334806] Systematic identification of interaction effects between genome- and environment-wide associations in type 2 diabetes mellitus.
[PMID 23460509] Replication of genetic effects of MC4R polymorphisms on body mass index in a Korean population.
[PMID 24911064] Association of FTO Polymorphisms with Obesity and Metabolic Parameters in Han Chinese Adolescents
[PMID 25177340] Phenome-wide association studies demonstrating pleiotropy of genetic variants within FTO with and without adjustment for body mass index
[PMID 25592819] FTO gene variants are not associated with polycystic ovary syndrome in women from Southern Brazil
[PMID 26309651] Correlation between polymorphism of FTO gene and type 2 diabetes mellitus in Uygur people from northwest China
[PMID 27274759] Interaction between FTO gene variants and lifestyle factors on metabolic traits in an Asian Indian population.
[PMID 27600277] Interaction between the obesity-risk gene FTO and the dopamine D2 receptor gene ANKK1/TaqIA on insulin sensitivity.