|substance dependence (SD) SNP|
|(C;C)||2.5||Associated with Alcohol Dependence; associated with nicotine dependence (female)|
[PMID 19052543] Interaction between two independent CNR1 variants increases risk for cocaine dependence in European Americans: a replication study in family-based sample and population-based sample.
[PMID 18213623] rs806368(C) together with rs1049353(A) or rs1049353(G) make up a haplotype associated with PTSD, with the C-A haplotype somewhat associated (p=0.04) with higher risk of PTSD and the C-G haplotype associated (p=0.01) with a lower risk of PTSD.
[PMID 22085192] Cannabinoid Receptor 1 Gene is Associated with Alcohol Dependence.
Alcoholic patients with TGT haplotype (corresponding to rs6454674-rs1049353-rs806368 polymorphisms in this order) were less prone to have AD (p = 0.017). TGC haplotype were more likely to develop AD.
[PMID 18179391] Association between single nucleotide polymorphisms in the cannabinoid receptor gene (CNR1) and impulsivity in southwest California Indians.
Impulsivity was significantly associated with the 6-repeat allele of the triplet repeat polymorphism (AATn/A6; p < .0001), as well as four SNPs in or near the CNR1 receptor gene: rs1535255 (p = .001), rs2023239 (p = .004), rs1049353 (p < .001) and rs806368 (p < .0006). These studies provide data to suggest that the CNR1 receptor gene may be significantly associated with impulsivity in SWC Indians.
[PMID 18606954] Cannabinoid receptor 1 gene association with nicotine dependence.
the associations were female specific. Haplotype 1-1-2 of markers rs2023239-rs12720071-rs806368(C) was associated with nicotine dependence and FTND score in the 2 samples (P < .001 and P = .009, respectively).
[PMID 18776593] Cannabinoid type-1 receptor gene polymorphisms are associated with central obesity in a Southern Brazilian population.
[PMID 19016476] Evidence for association between polymorphisms in the cannabinoid receptor 1 (CNR1) gene and cannabis dependence.
[PMID 19018721] Genetic variation in cannabinoid receptor 1 (CNR1) is associated with derangements in lipid homeostasis, independent of body mass index.
[PMID 19335651] Candidate genes for cannabis use disorders: findings, challenges and directions.
[PMID 19886064] The implication of CNR1 gene's polymorphisms in the modulation of endocannabinoid system effects.
[PMID 20415562] Role of genetic variation in the cannabinoid type 1 receptor gene (CNR1) in the pathophysiology of human obesity.
[PMID 20838400] Are endocannabinoid type 1 receptor gene (CNR1) polymorphisms associated with obesity and metabolic syndrome in postmenopausal Polish women?
[PMID 21129839] A common variation in the cannabinoid 1 receptor (CNR1) gene is associated with pre-eclampsia in the Central European population.
[PMID 21695734] Cannabinoid type 1 receptor gene polymorphisms are not associated with olanzapine-induced weight gain.
[PMID 21790903] Further evidence for association of polymorphisms in the CNR1 gene with cocaine addiction: confirmation in an independent sample and meta-analysis.
[PMID 24407958] Risky alcohol consumption in young people is associated with the fatty acid amide hydrolase gene polymorphism C385A and affective rating of drug pictures
[PMID 23407780] Screening genetic variability at the CNR1 gene in both major depression etiology and clinical response to citalopram treatment.
[PMID 25093427] Selected CNR1 polymorphisms and hyperandrogenemia as well as fat mass and fat distribution in women with polycystic ovary syndrome
[PMID 25136364] Cannabinoid receptor 1 gene polymorphisms and nonalcoholic Fatty liver disease in women with polycystic ovary syndrome and in healthy controls
[PMID 26756393] Longitudinal predictors of cannabis use and dependence in offspring from families at ultra high risk for alcohol dependence and in control families.