Have questions? Visit https://www.reddit.com/r/SNPedia

rs8067378

From SNPedia

childhood asthma
Orientationplus
Stabilizedplus
Make rs8067378(A;A)
Make rs8067378(A;G)
Make rs8067378(G;G)
ReferenceGRCh38 38.1/141
Chromosome17
Position39895095
is asnp
is mentioned by
dbSNPrs8067378
ebirs8067378
HLIrs8067378
Exacrs8067378
Varsomers8067378
Maprs8067378
PheGenIrs8067378
hapmaprs8067378
1000 genomesrs8067378
hgdprs8067378
ensemblrs8067378
gopubmedrs8067378
geneviewrs8067378
scholarrs8067378
googlers8067378
pharmgkbrs8067378
gwascentralrs8067378
openSNPrs8067378
23andMers8067378
23andMe allrs8067378
SNP Nexus

SNPshotrs8067378
SNPdbers8067378
MSV3drs8067378
GWAS Ctlgrs8067378
GMAF0.4578
Max Magnitude
? (A;A) (A;G) (G;G) 28
rs8067378 is the strongest associating SNP from a region of chromosome 17q21 found in a large (ultimately over 7,000 patients in 3 populations) genome-wide association study of childhood asthma.[PMID 17611496]

Since the associated SNPs were also strongly associated (p < 10-22) in cis with transcript levels of from the ORMDL3 gene, the authors concluded that genetic variants regulating ORMDL3 expression are determinants of susceptibility to childhood asthma.[PMID 17611496]

GWAS snp
PMID [PMID 20228799OA-icon.png]
Trait Ulcerative colitis
Title Genome-wide association identifies multiple ulcerative colitis susceptibility loci
Risk Allele A
P-val 1E-7
Odds Ratio 1.12 [NR]
OMIM611403
Desc
Variant
Relatedalso


[PMID 22370936] Genetic variants on 17q21 are associated with asthma in a Han Chinese population

[PMID 19264973OA-icon.png] Assessing the reproducibility of asthma candidate gene associations, using genome-wide data.

[PMID 19426955OA-icon.png] Genome-wide association analysis identifies PDE4D as an asthma-susceptibility gene.

[PMID 19714205OA-icon.png] Genome-wide association study implicates chromosome 9q21.31 as a susceptibility locus for asthma in mexican children.

[PMID 19732864OA-icon.png] Allele-specific chromatin remodeling in the ZPBP2/GSDMB/ORMDL3 locus associated with the risk of asthma and autoimmune disease.

[PMID 20698975OA-icon.png] Asthma-susceptibility variants identified using probands in case-control and family-based analyses.

GWAS snp
PMID [PMID 23817570]
Trait Cervical cancer
Title A genome-wide association study identifies two new cervical cancer susceptibility loci at 4q12 and 17q12.
Risk Allele G
P-val 9E-10
Odds Ratio 1.19 [1.13-1.26]