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rs8089

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(G;G) slightly increased heart attack risk
(G;T) slightly increased heart attack risk
(T;T) 0 normal risk
ReferenceGRCh38 38.1/141
Chromosome6
Position169217631
GeneTHBS2
is asnp
is mentioned by
dbSNPrs8089
ebirs8089
HLIrs8089
Exacrs8089
Varsomers8089
Maprs8089
PheGenIrs8089
hapmaprs8089
1000 genomesrs8089
hgdprs8089
ensemblrs8089
gopubmedrs8089
geneviewrs8089
scholarrs8089
googlers8089
pharmgkbrs8089
gwascentralrs8089
openSNPrs8089
23andMers8089
23andMe allrs8089
SNP Nexus

SNPshotrs8089
SNPdbers8089
MSV3drs8089
GWAS Ctlgrs8089
GMAF0.1823
Max Magnitude0
? (G;G) (G;T) (T;T) 28
rs8089, a SNP in the thrombospondin-2 THBS2 gene, was studied as part of a large study (>5,000 Caucasian patients) for risk of myocardial infarction and thus heart disease. Although statistically not overwhelming, a risk was seen (odds ratio 1.19, CI: 1.02-1.39, compared to (T;T) homozygotes) for carriers of the less common rs8089(G) allele. In a meta-analysis combining several studies, no statistically significant association for heart attacks was seen for rs8089, nor for that matter, 2 other SNPs, rs2228262 (also known as Asn700Ser) or rs1866389 (also known as Ala387Pro), in thrombospondins -1 and -4, respectively.[PMID 18178577]

[PMID 18455130OA-icon.png] A functional polymorphism in THBS2 that affects alternative splicing and MMP binding is associated with lumbar-disc herniation.

[PMID 21762961] An association study of thrombospondin 1 and 2 SNPs with coronary artery disease and myocardial infarction among South Indians.


[PMID 25664109OA-icon.png] Impact of thrombospondin-2 gene variations on the risk of thoracic aortic dissection in a Chinese Han population