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rs8103142

From SNPedia

Orientationplus
Stabilizedplus
Make rs8103142(C;C)
Make rs8103142(C;T)
Make rs8103142(T;T)
ReferenceGRCh38 38.1/141
Chromosome19
Position39244466
GeneIFNL3
is asnp
is mentioned by
dbSNPrs8103142
ebirs8103142
HLIrs8103142
Exacrs8103142
Varsomers8103142
Maprs8103142
PheGenIrs8103142
hapmaprs8103142
1000 genomesrs8103142
hgdprs8103142
ensemblrs8103142
gopubmedrs8103142
geneviewrs8103142
scholarrs8103142
googlers8103142
pharmgkbrs8103142
gwascentralrs8103142
openSNPrs8103142
23andMers8103142
23andMe allrs8103142
SNP Nexus

SNPshotrs8103142
SNPdbers8103142
MSV3drs8103142
GWAS Ctlgrs8103142
GMAF0.2952
Max Magnitude

[PMID 19749757] Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C

OMIM607402
DescINTERLEUKIN 28B; IL28B
Variant
Relatedalso



[PMID 21070502] Interleukin-28B polymorphisms are associated with hepatitis C virus clearance and viral load in a HIV-1-infected cohort

OMIM609532
Desc
Variant
Relatedalso


[PMID 22234924] Combined effects of different IL28B gene variants on the outcome of dual combination therapy in chronic HCV type 1 infection


[PMID 22295096OA-icon.png] Genetic Variations in IL28B and Allergic Disease in Children


[PMID 22328925OA-icon.png] Deciphering the Interleukin 28B Variants That Better Predict Response to Pegylated Interferon-? and Ribavirin Therapy in HCV/HIV-1 Coinfected Patients


[PMID 22649509OA-icon.png] IL28B Genetic Variation Is Associated with Spontaneous Clearance of Hepatitis C Virus, Treatment Response, Serum IL-28B Levels in Chinese Population

[PMID 20887330] High sensitivity assay using serum sample for IL28B genotyping to predict treatment response in chronic hepatitis C patients.

[PMID 21360716OA-icon.png] Estimating the net contribution of interleukin-28B variation to spontaneous hepatitis C virus clearance.

[PMID 21389156OA-icon.png] The rs8099917 polymorphism, when determined by a suitable genotyping method, is a better predictor for response to pegylated alpha interferon/ribavirin therapy in Japanese patients than other single nucleotide polymorphisms associated with interleukin-28B.


GET Evidence
IL28B-K70R
aa_change Lys70Arg
aa_change_short K70R
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.395349
summary



[PMID 22719902OA-icon.png] Analysis of IL28B variants in an Egyptian population defines the 20 kilobases minimal region involved in spontaneous clearance of hepatitis C virus


[PMID 23109451] IL28B polymorphisms predict the response to chronic hepatitis C virus infection treatment in a Mexican population


[PMID 23866096] The predictive value of IL28B rs12979860, rs11881222 and rs8099917 polymorphisms and IP-10 in the therapeutic response of Egyptian genotype 4 patients


[PMID 25032184OA-icon.png] No association between the IL28B SNP and response to peginterferon plus ribavirin combination treatment in Korean chronic hepatitis C patients


[PMID 25803108OA-icon.png] Favourable IFNL3 Genotypes Are Associated with Spontaneous Clearance and Are Differentially Distributed in Aboriginals in Canadian HIV-Hepatitis C Co-Infected Individuals