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rs8179673

From SNPedia

Orientationplus
Stabilizedplus
Make rs8179673(C;C)
Make rs8179673(C;T)
Make rs8179673(T;T)
ReferenceGRCh38 38.1/141
Chromosome2
Position191104615
GeneSTAT4
is asnp
is mentioned by
dbSNPrs8179673
ebirs8179673
HLIrs8179673
Exacrs8179673
Varsomers8179673
Maprs8179673
PheGenIrs8179673
hapmaprs8179673
1000 genomesrs8179673
hgdprs8179673
ensemblrs8179673
gopubmedrs8179673
geneviewrs8179673
scholarrs8179673
googlers8179673
pharmgkbrs8179673
gwascentralrs8179673
openSNPrs8179673
23andMers8179673
23andMe allrs8179673
SNP Nexus

SNPshotrs8179673
SNPdbers8179673
MSV3drs8179673
GWAS Ctlgrs8179673
GMAF0.2539
Max Magnitude
? (C;C) (C;T) (T;T) 28
OMIM180300
DescRHEUMATOID ARTHRITIS; RA
Variant
Relatedalso
OMIM600558
DescSIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 4; STAT4
Variant
Relatedalso


[PMID 19737838] A haplotype in STAT4 gene associated with rheumatoid arthritis in Caucasians is not associated in the Han Chinese population, but with the presence of rheumatoid factor


[PMID 20176035] Association of signal transducer and activator of transcription 4 genetic variants with extra-intestinal manifestations in inflammatory bowel disease


[PMID 21683716] Signal transducer and activator of transcription 4 gene polymorphisms associated with rheumatoid arthritis in Northwestern Chinese Han population

[PMID 17932559OA-icon.png] Association of STAT4 with rheumatoid arthritis in the Korean population.

[PMID 18434327OA-icon.png] Re-evaluation of putative rheumatoid arthritis susceptibility genes in the post-genome wide association study era and hypothesis of a key pathway underlying susceptibility.

[PMID 18516230OA-icon.png] Specificity of the STAT4 genetic association for severe disease manifestations of systemic lupus erythematosus.

[PMID 18579578OA-icon.png] A risk haplotype of STAT4 for systemic lupus erythematosus is over-expressed, correlates with anti-dsDNA and shows additive effects with two risk alleles of IRF5.

[PMID 19120275] STAT4 polymorphism is associated with early-onset type 1 diabetes, but not with late-onset type 1 diabetes.

[PMID 19674979OA-icon.png] Overlap of disease susceptibility loci for rheumatoid arthritis and juvenile idiopathic arthritis.

[PMID 20454450OA-icon.png] Evidence for STAT4 as a common autoimmune gene: rs7574865 is associated with colonic Crohn's disease and early disease onset.

[PMID 22569826] Abnormal Genetic and Epigenetic Changes in Signal Transducer and Activator of Transcription 4 in the Pathogenesis of Inflammatory Bowel Diseases.