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rs821616

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(A;A) cognitive decline in older women
(A;T)  ?
(T;T) normal
ReferenceGRCh38 38.1/141
Chromosome1
Position232008852
GeneDISC1, MAP1LC3C
is asnp
is mentioned by
dbSNPrs821616
ebirs821616
HLIrs821616
Exacrs821616
Varsomers821616
Maprs821616
PheGenIrs821616
hapmaprs821616
1000 genomesrs821616
hgdprs821616
ensemblrs821616
gopubmedrs821616
geneviewrs821616
scholarrs821616
googlers821616
pharmgkbrs821616
gwascentralrs821616
openSNPrs821616
23andMers821616
23andMe allrs821616
SNP Nexus

SNPshotrs821616
SNPdbers821616
MSV3drs821616
GWAS Ctlgrs821616
GMAF0.2484
Max Magnitude
? (A;A) (A;T) (T;T) 28
Women with two rs821616(T) SNPs seem to experience more rapid cognitive decline as they age compared to men. [PMID 16054297]

[PMID 17673452] 13 single-nucleotide polymorphisms (SNPs) in 723 members of 179 Finnish Bipolar disorder families.

  • rs821616 verbal fluency


Venter snp
Source plos
Gene DISC1
allele T
frequency 0.308
sift TOLERATED
HuRef 1103675362829
Disease Association A chromosomal aberration involving DISC1 segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Translocation t(1;11)(q42.1;q14.3).



[PMID 19805229OA-icon.png] DISC1 splice variants are upregulated in schizophrenia and associated with risk polymorphisms


[PMID 21878470OA-icon.png] Effect of DISC1 on the P300 Waveform in Psychosis


[PMID 22673686] Gender-specific association of TSNAX/DISC1 locus for schizophrenia and bipolar affective disorder in South Indian population


[PMID 15386212OA-icon.png] Disrupted in schizophrenia 1 (DISC1): association with schizophrenia, schizoaffective disorder, and bipolar disorder.


[PMID 15939883OA-icon.png] Variation in DISC1 affects hippocampal structure and function and increases risk for schizophrenia.


[PMID 17286247] Positive association of the Disrupted-in-Schizophrenia-1 gene (DISC1) with schizophrenia in the Chinese Han population.


[PMID 17997036] Association study of polymorphisms between DISC1 and schizophrenia in a Korean population.


[PMID 18072279OA-icon.png] Combining fMRI and SNP data to investigate connections between brain function and genetics using parallel ICA.


[PMID 19188535OA-icon.png] Association of variants in DISC1 with psychosis-related traits in a large population cohort.


[PMID 19300510OA-icon.png] The DISC1 pathway modulates expression of neurodevelopmental, synaptogenic and sensory perception genes.


[PMID 19414483OA-icon.png] The DISC locus and schizophrenia: evidence from an association study in a central European sample and from a meta-analysis across different European populations.


[PMID 20403199OA-icon.png] High-throughput analysis of candidate imprinted genes and allele-specific gene expression in the human term placenta.


[PMID 20531374] Association of Disrupted in Schizophrenia 1 (DISC1) missense variants with ultra-resistant schizophrenia.


GET Evidence
DISC1-S736C
aa_change Ser736Cys
aa_change_short S736C
impact not reviewed
qualified_impact Insufficiently evaluated not reviewed
overall_frequency
summary



[PMID 23140672] DISC1 (disrupted-in-schizophrenia 1) is associated with cortical grey matter volumes in the human brain: a voxel-based morphometry (VBM) study


[PMID 23602339] Human brain imaging studies of DISC1 in schizophrenia, bipolar disorder and depression: a systematic review.


[PMID 25670952OA-icon.png] Disrupted-in-Schizophrenia-1 SNPs and Susceptibility to Schizophrenia: Evidence from Malaysia


[PMID 26945459] Association study of DISC1 genetic variants with the risk of schizophrenia.