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rs828907

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(G;G) 1 Normal risk of developing bladder cancer
(G;T) 2 Slightly increased risk of bladder cancer and 2x risk of developing bladder cancer in smokers
(T;T) 2 Increased risk of bladder cancer and 2x risk of developing bladder cancer in smokers
ReferenceGRCh38 38.1/141
Chromosome2
Position216108009
GeneXRCC5
is asnp
is mentioned by
dbSNPrs828907
ebirs828907
HLIrs828907
Exacrs828907
Varsomers828907
Maprs828907
PheGenIrs828907
hapmaprs828907
1000 genomesrs828907
hgdprs828907
ensemblrs828907
gopubmedrs828907
geneviewrs828907
scholarrs828907
googlers828907
pharmgkbrs828907
gwascentralrs828907
openSNPrs828907
23andMers828907
23andMe allrs828907
SNP Nexus

SNPshotrs828907
SNPdbers828907
MSV3drs828907
GWAS Ctlgrs828907
GMAF0.2957
Max Magnitude2
? (G;G) (G;T) (T;T) 28
rs828907, also known as G-1401T, is a SNP in the Ku80 gene.

A study of 288 Chinese patients with bladder cancer and 288 age- and gender-matched healthy controls found that the rs828907(T) allele conferred a significant (p=0.0055) increased risk of bladder cancer. In association with smoking, the (G;T) and (T;T) genotypes conferred a 2x risk (CI:1.232-3.419) for bladder cancer.[PMID 19414375]

[PMID 19217823] correlated with oral cancer susceptibility


[PMID 19528488] Significant Association of Ku80 Single Nucleotide Polymorphisms with Colorectal Cancer Susceptibility in Central Taiwan


[PMID 20044645] Significant Association of DNA Repair Gene Ku80 Genotypes with Breast Cancer Susceptibility in Taiwan


[PMID 23098447] Association between XRCC5, 6 and 7 gene polymorphisms and the risk of breast cancer: a HuGE review and meta-analysis