rs861539, also known as c.722C>T, p.Thr241Met and T241M, is a SNP in the XRCC3 gene on chromosome 14. The somewhat more common rs861539(C) allele leads to the Thr (T); the somewhat less common rs861539(T) is associated with the Met (M).
A meta-analysis of three studies (each over 500 cases) found a significant - though slight - association for melanoma for the rs861539(Thr/Thr vs. Met/Thr: OR 1.20, CI: 1.04-1.38; dominant model: OR 0.86, CI: 0.75-0.98).[PMID 26137085]
pseudo-haplotype with AG-CC genotypes in
- 2.45x risk rs2040639-rs861539
- 5.03x risk rs2040639-rs861539-rs2075685
- 10.10x risk rs2040639-rs861539-rs2075685-rs1799782
rs4880(C;T) prostate cancer patients being treated by radiation therapy are more likely (8% compared to 0%, p=0.02) to exhibit a significant increase in grade 2 late rectal bleeding after irradiation than (C;C) or (T;T) patients, based on a study of 135 patients. The odds for this are worse if the patient also has the rs861539(C;T) genotype (14% vs 1%, p=0.002).[PMID 18582155]
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|Disease||Cutaneous malignant melanoma 6|
|CLNDBN||Cutaneous malignant melanoma 6|
|CLNSRC||OMIM Allelic Variant|
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