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rs864745

From SNPedia

Orientationminus
Stabilizedminus
Make rs864745(A;A)
Make rs864745(A;G)
Make rs864745(G;G)
ReferenceGRCh38 38.1/141
Chromosome7
Position28140937
GeneJAZF1
is asnp
is mentioned by
dbSNPrs864745
ebirs864745
HLIrs864745
Exacrs864745
Varsomers864745
Maprs864745
PheGenIrs864745
hapmaprs864745
1000 genomesrs864745
hgdprs864745
ensemblrs864745
gopubmedrs864745
geneviewrs864745
scholarrs864745
googlers864745
pharmgkbrs864745
gwascentralrs864745
openSNPrs864745
23andMers864745
23andMe allrs864745
SNP Nexus

SNPshotrs864745
SNPdbers864745
MSV3drs864745
GWAS Ctlgrs864745
GMAF0.3549
Max Magnitude
? (A;A) (A;G) (G;G) 28
GWAS
SNP rs864745
PubMedID [PMID 18372903OA-icon.png]
Condition Type 2 diabetes
Gene JAZF1
Risk Allele T
pValue 5.00E-014
OR 1.1
95% CI 1.07-1.13


[PMID 19455301] Replication study for the association of new meta-analysis-derived risk loci with susceptibility to type 2 diabetes in 6,244 Japanese individuals


[PMID 19789630OA-icon.png] Variant near ADAMTS9 known to associate with type 2 diabetes is related to insulin resistance in offspring of type 2 diabetes patients--EUGENE2 study


[PMID 20018066OA-icon.png] Epistatic interactions of CDKN2B-TCF7L2 for risk of type 2 diabetes and of CDKN2B-JAZF1 for triglyceride/high-density lipoprotein ratio longitudinal change: evidence from the Framingham Heart Study


[PMID 20406958OA-icon.png] Refining the Prostate Cancer Genetic Association within the JAZF1 Gene on Chromosome 7p15.2


[PMID 20927120] Variations in/nearby genes coding for JAZF1, TSPAN8/LGR5 and HHEX-IDE and risk of type 2 diabetes in Han Chinese


[PMID 18567820OA-icon.png] Association testing of novel type 2 diabetes risk alleles in the JAZF1, CDC123/CAMK1D, TSPAN8, THADA, ADAMTS9, and NOTCH2 loci with insulin release, insulin sensitivity, and obesity in a population-based sample of 4,516 glucose-tolerant middle-aged Danes.


[PMID 18591388OA-icon.png] Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk.


[PMID 18694974OA-icon.png] Predicting type 2 diabetes based on polymorphisms from genome-wide association studies: a population-based study.


[PMID 18714373OA-icon.png] Novel meta-analysis-derived type 2 diabetes risk loci do not determine prediabetic phenotypes.


[PMID 18782870OA-icon.png] Clinical review: the genetics of type 2 diabetes: a realistic appraisal in 2008.


[PMID 18852197OA-icon.png] Metabolic and cardiovascular traits: an abundance of recently identified common genetic variants.


[PMID 19020323OA-icon.png] Genotype score in addition to common risk factors for prediction of type 2 diabetes.


[PMID 19056611OA-icon.png] Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data.


[PMID 19096518OA-icon.png] Novel association of HK1 with glycated hemoglobin in a non-diabetic population: a genome-wide evaluation of 14,618 participants in the Women's Genome Health Study.


[PMID 19207020OA-icon.png] Meta-analysis in genome-wide association studies.


[PMID 19323962OA-icon.png] Genome-wide association studies in type 2 diabetes.


[PMID 19324937OA-icon.png] Previously associated type 2 diabetes variants may interact with physical activity to modify the risk of impaired glucose regulation and type 2 diabetes: a study of 16,003 Swedish adults.


[PMID 19341491OA-icon.png] Genome-based prediction of common diseases: methodological considerations for future research.


[PMID 19401414OA-icon.png] Confirmation of multiple risk Loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population.


[PMID 19460916OA-icon.png] Genetic architecture of type 2 diabetes: recent progress and clinical implications.


[PMID 19474294OA-icon.png] Potential etiologic and functional implications of genome-wide association loci for human diseases and traits.


[PMID 19502414OA-icon.png] Association of 18 confirmed susceptibility loci for type 2 diabetes with indices of insulin release, proinsulin conversion, and insulin sensitivity in 5,327 nondiabetic Finnish men.


[PMID 19526209OA-icon.png] Is the thrifty genotype hypothesis supported by evidence based on confirmed type 2 diabetes- and obesity-susceptibility variants?


[PMID 19602701OA-icon.png] Underlying genetic models of inheritance in established type 2 diabetes associations.


[PMID 19639606OA-icon.png] Correcting "winner's curse" in odds ratios from genomewide association findings for major complex human diseases.


[PMID 19741467] Association of common type 2 diabetes risk gene variants and posttransplantation diabetes mellitus in renal allograft recipients in Korea.


[PMID 19956539OA-icon.png] How many genetic variants remain to be discovered?


[PMID 20017978OA-icon.png] Influence of control selection in genome-wide association studies: the example of diabetes in the Framingham Heart Study.


[PMID 20043853OA-icon.png] Prioritizing genes for follow-up from genome wide association studies using information on gene expression in tissues relevant for type 2 diabetes mellitus.


[PMID 20075150OA-icon.png] Utility of genetic and non-genetic risk factors in prediction of type 2 diabetes: Whitehall II prospective cohort study.


[PMID 20144327OA-icon.png] A genomics study of type 2 diabetes mellitus in U.S. Air Force personnel.


[PMID 20161779OA-icon.png] Investigation of type 2 diabetes risk alleles support CDKN2A/B, CDKAL1, and TCF7L2 as susceptibility genes in a Han Chinese cohort.


[PMID 20712903OA-icon.png] Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study.


[PMID 21278902OA-icon.png] Genetic risk profiling for prediction of type 2 diabetes.


[PMID 21602532OA-icon.png] Type 2 diabetes risk variants and colorectal cancer risk: the Multiethnic Cohort and PAGE studies.


[PMID 22377712] Association between type 2 diabetes genetic susceptibility loci and visceral and subcutaneous fat area as determined by computed tomography.


GET Evidence
rs864745
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.34127
summary



GWAS snp
PMID [PMID 23128233OA-icon.png]
Trait Crohn's disease
Title Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
Risk Allele T
P-val 4E-9
Odds Ratio 1.09 [1.052-1.123]


[PMID 23036851] Treatment factors rather than genetic variation determine metabolic syndrome in childhood cancer survivors


[PMID 23298195] Association study of genetic variants of 17 diabetes-related genes/loci and cardiovascular risk and diabetic nephropathy in the Chinese She population.


[PMID 23456907OA-icon.png] Maternal genotype and gestational diabetes.


[PMID 23462794OA-icon.png] Identification of CpG-SNPs associated with type 2 diabetes and differential DNA methylation in human pancreatic islets.


[PMID 25785549] The Uyghur Population and Genetic Susceptibility to Type 2 Diabetes: Potential Role for Variants in CDKAL1, JAZF1, and IGF1 Genes


[PMID 26337813] The impact of PNPLA3 and JAZF1 on hepatocellular carcinoma in non-viral hepatitis patients with type 2 diabetes mellitus