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rs874881

From SNPedia

Orientationplus
Stabilizedplus
Make rs874881(C;C)
Make rs874881(C;G)
Make rs874881(G;G)
ReferenceGRCh38 38.1/141
Chromosome1
Position17334004
GenePADI4
is asnp
is mentioned by
dbSNPrs874881
ebirs874881
HLIrs874881
Exacrs874881
Varsomers874881
Maprs874881
PheGenIrs874881
hapmaprs874881
1000 genomesrs874881
hgdprs874881
ensemblrs874881
gopubmedrs874881
geneviewrs874881
scholarrs874881
googlers874881
pharmgkbrs874881
gwascentralrs874881
openSNPrs874881
23andMers874881
23andMe allrs874881
SNP Nexus

SNPshotrs874881
SNPdbers874881
MSV3drs874881
GWAS Ctlgrs874881
GMAF0.4908
Max Magnitude
? (C;C) (C;G) (G;G) 28


Venter snp
Source plos
Gene PADI4
allele C
frequency 0.45
sift TOLERATED
HuRef 1103675033977
Disease Association PADI4 is thought to be a rheumatoid arthritis susceptibility locus (MIM:180300). Could have an important role in the pathogenesis of rheumatoid arthritis by increasing citrullination of proteins in rheumatoid arthritis synovial tissues, leading, in a cytokine-rich milieu, to a break in tolerance to citrullinated peptides processed and presented in the appropriate HLA context.



[PMID 20563870] The PADI4 gene does not contribute to genetic susceptibility to rheumatoid arthritis in Chinese Han population


[PMID 18576335OA-icon.png] Association of autoimmunity to peptidyl arginine deiminase type 4 with genotype and disease severity in rheumatoid arthritis.


[PMID 20537173OA-icon.png] Peptidyl arginine deiminase type IV (PADI4) haplotypes interact with shared epitope regardless of anti-cyclic citrullinated peptide antibody or erosive joint status in rheumatoid arthritis: a case control study.


[PMID 21039740] PADI4 gene polymorphism is not associated with ankylosing spondylitis in Chinese Han population.


[PMID 22505706] Peptidylarginine deiminase type 4 and methyl-CpG binding domain 4 polymorphisms in Chinese patients with rheumatoid arthritis.


[PMID 22976394] Association of single nucleotide polymorphisms (SNPs) of PADI4 gene with rheumatoid arthritis (RA) in Indian population


GET Evidence
PADI4-G112A
aa_change Gly112Ala
aa_change_short G112A
impact not reviewed
qualified_impact Insufficiently evaluated not reviewed
overall_frequency 0.528165
summary



[PMID 23450494] [Association of polymorphisms of PTPN22 and PADI4 genes with rheumatoid arthritis in Yunnan]


[PMID 27182695] PADI4 Polymorphisms in Iranian Patients with Rheumatoid Arthritis.