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rs884205

From SNPedia

Orientationminus
Stabilizedminus
Make rs884205(G;G)
Make rs884205(G;T)
Make rs884205(T;T)
ReferenceGRCh38 38.1/141
Chromosome18
Position62387624
GeneTNFRSF11A
is asnp
is mentioned by
dbSNPrs884205
ebirs884205
HLIrs884205
Exacrs884205
Varsomers884205
Maprs884205
PheGenIrs884205
hapmaprs884205
1000 genomesrs884205
hgdprs884205
ensemblrs884205
gopubmedrs884205
geneviewrs884205
scholarrs884205
googlers884205
pharmgkbrs884205
gwascentralrs884205
openSNPrs884205
23andMers884205
23andMe allrs884205
SNP Nexus

SNPshotrs884205
SNPdbers884205
MSV3drs884205
GWAS Ctlgrs884205
GMAF0.1882
Max Magnitude
? (G;G) (G;T) (T;T) 28
GWAS snp
PMID [PMID 19801982OA-icon.png]
Trait Bone mineral density (spine)
Title Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies
Risk Allele A
P-val 9E-9
Odds Ratio 0.08 [0.05-0.11] sd decrease


[PMID 22370887OA-icon.png] Are bone mineral density loci associated with hip osteoporotic fractures? A validation study on previously reported genome-wide association loci in a Chinese population


[PMID 16960694OA-icon.png] Is a gene important for bone resorption a candidate for obesity? An association and linkage study on the RANK (receptor activator of nuclear factor-kappaB) gene in a large Caucasian sample.


[PMID 17002564OA-icon.png] Robust and comprehensive analysis of 20 osteoporosis candidate genes by very high-density single-nucleotide polymorphism screen among 405 white nuclear families identified significant association and gene-gene interaction.


[PMID 18466469OA-icon.png] Genome-wide analysis of single-locus and epistasis single-nucleotide polymorphism effects on anti-cyclic citrullinated peptide as a measure of rheumatoid arthritis.


[PMID 19458885OA-icon.png] Association analyses of RANKL/RANK/OPG gene polymorphisms with femoral neck compression strength index variation in Caucasians.

GWAS snp
PMID [PMID 22504420OA-icon.png]
Trait
Title Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.
Risk Allele A
P-val 2E-17
Odds Ratio 0.0500 None


GET Evidence
rs884205
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.888889
summary



GWAS snp
PMID [PMID 24945404OA-icon.png]
Trait Bone mineral density (paediatric, skull)
Title Phenotypic dissection of bone mineral density reveals skeletal site specificity and facilitates the identification of novel loci in the genetic regulation of bone mass attainment.
Risk Allele C
P-val 2E-8
Odds Ratio .10 [0.069-0.139] unit increase